Estrogen actions in the central nervous system

This article will review the neural actions of estrogens in the central nervous system, focusing on brain structures outside of the hypothalamus and on neurally mediated processes other than reproductive behavior and reproductive neuroendocrine events. We do this, however, in the context of what is...

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Bibliographic Details
Published in:	Endocrine reviews Vol. 20; no. 3; pp. 279 - 307
Main Authors:	McEwen, B S, Alves, S E
Format:	Journal Article
Language:	English
Published:	United States 01-06-1999
Subjects:	Alzheimer Disease Animals Central Nervous System - cytology Central Nervous System - drug effects Central Nervous System - physiology Estrogens - pharmacology Estrogens - physiology Female Gene Expression Regulation - drug effects Humans Hypothalamus - cytology Hypothalamus - drug effects Hypothalamus - physiology Learning - drug effects Memory - drug effects progestin
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Summary:	This article will review the neural actions of estrogens in the central nervous system, focusing on brain structures outside of the hypothalamus and on neurally mediated processes other than reproductive behavior and reproductive neuroendocrine events. We do this, however, in the context of what is known about estrogen actions in the hypothalamus. In this summary of the recent scientific literature, we place particular emphasis on estrogen and progestin effects in the hippocampal formation, as well as basal forebrain of the rat, because these brain structures are prominent in learning and memory and also are sites of neural degeneration in dementing illnesses such as Alzheimer's disease.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0163-769X
DOI:	10.1210/er.20.3.279