Synthesis and comparative evaluation of the antioxidant activity for some new derivatives of 2,6-diisobornylphenol bearing an aminomethyl group at the position 4

• Published in: Russian chemical bulletin Vol. 70; no. 1; pp. 183 - 190
• Main Authors: Buravlev, E. V., Shevchenko, O. G., Kutchin, A. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 2021; Springer Nature B.V
• Subjects: Antioxidants; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Full Articles; Inorganic Chemistry; Organic Chemistry; Synthesis; membrane protective activity; oxidative hemolysis; erythrocytes; isobornylphenols; aminomethyl derivatives; antioxidant activity
• ISSN: 1066-5285; 1573-9171
• DOI: 10.1007/s11172-021-3075-9

New derivatives of 2,6-diisobornylphenol containing (phenylamino)methyl or (benzylamino)methyl moiety, or heterocyclic (1
H
-benzo[
d
]imidazol-1-yl)methyl, (2-benzyl-1
H
-benzo[
d
]imidazol-1-yl)methyl, or (1
H
-benzo[
d
][1,2,3]triazol-1-yl)methyl substituent at the
para
-position relative to the hydroxy group were synthesized. A comparative evaluation of the antioxidant activity was carried out using
in vitro
models for the most of compounds obtained. The activity of synthesized derivatives depends on the test system used and, in some cases, may be related to a membrane stabilizing effect.