Synthesis and characterization of novel silica coated magnetic nanoparticles with tags of β-cyclodextrin: application as an eco-friendly and chiral micro-vessel catalyst in the enantioselective reduction of ketones

• Published in: Research on chemical intermediates Vol. 44; no. 4; pp. 2719 - 2728
• Main Authors: Jafari Nasab, Mina, Kiasat, Ali Reza
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-04-2018; Springer Nature B.V
• Subjects: Catalysis; Catalysts; Chemistry; Chemistry and Materials Science; Cyclodextrins; Electron microscopy; Fourier transforms; Infrared spectroscopy; Inorganic Chemistry; Iron oxides; Ketones; Nanocomposites; Nanoparticles; Physical Chemistry; Reduction; Silicon dioxide; Synthesis; Thermogravimetric analysis; β-Cyclodextrin; Organic–inorganic magnetic nanocomposite; Enantiomeric reduction of ketones; Modified silica-coated magnetic nanoparticle
• ISSN: 0922-6168; 1568-5675
• DOI: 10.1007/s11164-018-3256-9

In this work, we report the synthesis of a novel, green and recoverable organic–inorganic magnetic nanocomposite by grafting β-cyclodextrin on the surface of a silica-coated magnetic nanoparticle, Fe
3
O
4
@SiO
2
/Pr-β-CD. FT-IR spectroscopy, transmission electron microscopy, CHN analysis, thermogravimetric analysis, vibrating sample magnetometer and X-ray diffraction analyses confirmed its structure. The magnetic core–shell structured modified silica microsphere has been successfully used as a chiral micro-vessel catalyst for the enantioselective reduction of ketones by NaBH
4
. The described catalyst was regenerated and reused without any significant changes in the yield and enantiomeric excess.