Vitamin E in renal therapeutic regimens

Vitamin E in renal therapeutic regimens

Administration of vitamin E in children with immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis (FSGS) and type I diabetes demonstrated potential towards ameliorating progression. Oral vitamin E therapy reduced endothelial dysfunction, lipid peroxidation and oxidative stress in p...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) Vol. 21; no. 12; pp. 1790 - 1801
Main Authors: Thabet, Mohamed Alaa, Chan, James C. M.
Format: Journal Article
Language:English
Published: Berlin Springer Nature B.V 01-12-2006
Subjects:
Antioxidants
Clinical trials
Diabetes
Endothelium
Kidney diseases
Kinases
Mortality
Oxidative stress
Proteins
Risk factors
Tumor necrosis factor-TNF
Vitamin E
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Summary:Administration of vitamin E in children with immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis (FSGS) and type I diabetes demonstrated potential towards ameliorating progression. Oral vitamin E therapy reduced endothelial dysfunction, lipid peroxidation and oxidative stress in patients with chronic kidney failure (CKF). Moreover, the use of vitamin E-bonded hemodialyzers reduced atherosclerotic changes, erythropoietin dosage and muscular cramps in patients on hemodialysis (HD). However, several controlled clinical trials failed to document beneficial effects on the study subjects' cardiovascular and renal outcomes. A recent report of increased all-cause mortality in adult patients receiving high dose vitamin E therapy has caused considerable concern and debate. These issues regarding the efficacy and safety of vitamin E in renal therapeutic regimens will be reviewed in this article. [PUBLICATION ABSTRACT]
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-006-0211-6