Nanoencapsulation of hybrid crude palm oil Unaué HIE OxG with jackfruit by-products as encapsulants: A study of cellular antioxidant activity and cytotoxicity in Caco-2 cells

• Published in: Food chemistry Vol. 448; p. 139009
• Main Authors: Assunção, Larissa Santos, Ribeiro, Camila Duarte Ferreira, de Souza, Carolina Oliveira, Danielski, Renan, Kumari, Sarika, Nunes, Itaciara Larroza, Shahidi, Fereidoon
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-08-2024
• Subjects: Antioxidant potential; Central axis of jackfruit; Elaeis guineensis; Elaeis oleifera; Jackfruit seed; Toxicity; Central axis of jackfruit; Toxicity; Elaeis guineensis; Jackfruit seed; Elaeis oleifera; Antioxidant potential
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2024.139009

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•Jackfruit by-products shows the potential to produce nanoparticles.•Nanoparticles with hybrid palm oil have high uniformity.•Cellular antioxidant activity of nanoparticles surpassed the free oil.•Nanoparticles exhibited no cytotoxic effects on differentiated Caco-2 cells.
Hybrid crude palm oil (HCPO) HIE OxG is notable for its abundance of carotenoids, tocopherols, and tocotrienols. Investigating cellular antioxidant activity (CAA) and the non-cytotoxicity of oil nanoparticles is crucial for understanding the behavior of these phytochemicals in biological systems and ensuring the safety of products. Nanoparticles of HCPO, encapsulated with jackfruit by-products were produced and characterized for CAA and cytotoxicity in Caco-2 cells. The nanoparticles exhibited nanoscale diameters (<250 nm), uniform distribution and stability (polydispersity index < 0.25; zeta potential JSF-NP −12.46 ± 0.15 mV and JAF-NP −13.73 ± 1.28 mV). JSF-NP and JAF-NP demonstrated superior CAA compared to the free HCPO across all concentrations, without inducing cytotoxic effects on differentiated Caco-2 cells. This study underscores the importance of investigating the CAA of edible oil nanoparticles, with non-cytotoxicity indicating biological safety and the potential to safeguard intestinal epithelial cells. Thus, JSF-NP and JAF-NP emerge as promising delivery systems for future HCPO applications.