Proton magnetic resonance spectroscopy in primary blepharospasm

• Published in: Neurology Vol. 51; no. 3; pp. 892 - 895
• Main Authors: FEDERICO, F, SIMONE, I. L, LUCIVERO, V, DEFAZIO, G, DE SALVIA, R, MEZZAPESA, D. M, PETRUZZELLIS, M, TORTORELLA, C, LIVREA, P
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01-09-1998
• Subjects: Aged; Aspartic Acid - analogs & derivatives; Aspartic Acid - analysis; Basal Ganglia - chemistry; Biological and medical sciences; Blepharospasm - diagnosis; Choline - analysis; Creatine - analysis; Diseases of striated muscles. Neuromuscular diseases; Female; Humans; Magnetic Resonance Spectroscopy; Male; Medical sciences; Middle Aged; Neurology; Phosphocreatine - analysis; Human; Nervous system diseases; Exploration; Basal ganglion; NMR spectrometry; Orbicularis oculi muscle; Metabolism; Involuntary movement; Striated muscle disease; Eye disease; Eyelid disease; Primary; Proton; Adult; Dystonia; Neurological disorder; Blepharospasm; Localized; Extrapyramidal syndrome
• ISSN: 0028-3878; 1526-632X
• DOI: 10.1212/WNL.51.3.892

Single-volume proton magnetic resonance spectroscopy, localized to basal ganglia, was carried out in 10 patients with primary blepharospasm (PB) to assess the levels of N-acetyl aspartate (NAA), creatine-phosphocreatine, and choline-containing compounds. NAA was reduced significantly in patients compared with control subjects. This result suggests a striatal neuronal loss in PB.