(±)-Pheharmines A-B, two pairs of racemic alkaloids with a morpholino[4,3,2- hi ]β-carboline core, from the roots of Peganum harmala

(±)-Pheharmines A-B, two pairs of racemic alkaloids with a morpholino[4,3,2- hi ]β-carboline core, from the roots of Peganum harmala

Two pairs of unprecedented β-carboline-phenylpropanoid heterogeneous alkaloids, (±)-pheharmines A-B (1-4), characterized by a morpholino[4,3,2- ]β-carboline core with two chiral centers, were isolated from the roots of . The structures, including their absolute configurations, were identified using...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry Vol. 20; no. 43; p. 8528
Main Authors: Li, Sheng-Ge, Hu, Xu, Zhang, Qin, Zan, Yan-Hui, Wang, Kai-Bo, Jiang, Chun-Yu, Xue, Jing-Jing, Liu, Yong-Xiang, Lin, Bin, Jing, Yong-Kui, Li, Da-Hong, Hua, Hui-Ming
Format: Journal Article
Language:English
Published: England 09-11-2022
Subjects:
Alkaloids - chemistry
Alkaloids - pharmacology
Carbolines - chemistry
Carbolines - pharmacology
Humans
Molecular Structure
Morpholinos - analysis
Morpholinos - metabolism
Peganum - chemistry
Peganum - metabolism
Seeds
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two pairs of unprecedented β-carboline-phenylpropanoid heterogeneous alkaloids, (±)-pheharmines A-B (1-4), characterized by a morpholino[4,3,2- ]β-carboline core with two chiral centers, were isolated from the roots of . The structures, including their absolute configurations, were identified using spectroscopic analyses and electronic circular dichroism (ECD) calculations. The biosynthetic hypothesis for the formation of pheharmines A-B was proposed. Compounds 1-4 exhibited moderate cytotoxic activities against HL-60 cell lines.
ISSN:1477-0539
DOI:10.1039/d2ob01608g