Deficiency of the beta subunit of the eighth component of complement presenting as arthritis and exanthem

A 13-year-old boy presented with juvenile chronic arthritis of 6 months' duration. Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected. Western blotting showed a deficiency of the beta subunit of the eighth component of complement. The same defic...

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Bibliographic Details
Published in:	Arthritis and rheumatism Vol. 37; no. 11; p. 1704
Main Authors:	Wulffraat, N M, Sanders, E A, Fijen, C A, Hannema, A, Kuis, W, Zegers, B J
Format:	Journal Article
Language:	English
Published:	United States 01-11-1994
Subjects:	Adolescent Adult Arthritis, Juvenile - etiology Arthritis, Juvenile - immunology Complement C8 - deficiency Complement C8 - genetics Exanthema - etiology Exanthema - immunology Family Health Female Heterozygote Humans Male Middle Aged
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Summary:	A 13-year-old boy presented with juvenile chronic arthritis of 6 months' duration. Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected. Western blotting showed a deficiency of the beta subunit of the eighth component of complement. The same deficiency was present in the patient's sister. C8 beta deficiency is usually detected in individuals who survive meningococcal disease. There was no such history in this family. Juvenile chronic arthritis has not previously been described in patients with C8 beta deficiency.
ISSN:	0004-3591
DOI:	10.1002/art.1780371121