Biocompatibility and characteristics of chitosan/cellulose acetate microspheres for drug delivery

• Published in: Frontiers of materials science Vol. 5; no. 4; pp. 367 - 378
• Main Authors: Zhou, Hui-Yun, Zhou, Dong-Ju, Zhang, Wei-Fen, Jiang, Ling-Juan, Li, Jun-Bo, Chen, Xi-Guang
• Format: Journal Article
• Language: English
• Published: Heidelberg SP Higher Education Press 01-12-2011
• Subjects: Chemistry and Materials Science; Materials Science; Research Article; SD大鼠; Sprague-Dawley; 壳聚糖; 微球; 生物相容性; 给药; 血液相容性; 醋酸纤维素; cellulose acetate; chitosan; CCAM; tissue compatibility; blood compatibility
• ISSN: 2095-025X; 2095-0268
• DOI: 10.1007/s11706-011-0146-0

In this work, chitosan/cellulose acetate microspheres （CCAM） were prepared by the method of WlO/W emulsion with no toxic reagents. The microspheres were spherical, free flowing, and non-aggregated, which had a narrow size distribution. More than 90% of the microspheres had the diameter ranging from 200 to 280 pm. The hemolytic analysis indicated that CCAM was safe and had no hemolytic effect. The implanted CCAM did not produce any significant changes in the hematology of Sprague- Dawley （SD） rats, such as white blood cell, red blood cell, platelet, and the volume of hemoglobin. In addition, the levels of serum alanine aminotransferase, blood urea nitrogen, and creatinine had no obvious changes in SD rats implanted with CCAM, surger thread, or normal SD rats without any implantation. Thus, the CCAM had good blood compatibility and had no hepatotoxicity or renal toxicity to SD rats. Furthermore, CCAM with or without the model drug had good tissue compatibility with respect to the inflammatory reaction in SD rats and showed no significant difference from that of SD rats implanted with surgery thread. CCAM shows promise as a long-acting delivery system, which had good biocompatibility and biodegradability.