A deep dive into future therapies for microcytic anemias and clinical considerations

Microcytic anemias (MA) have frequent or rare etiologies. New discoveries in understanding and treatment of microcytic anemias need to be reviewed. Microcytic anemias with a focus on the most frequent causes and on monogenic diseases that are relevant for understanding biocellular mechanisms of MA....

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Bibliographic Details
Published in:	Expert review of hematology Vol. 16; no. 5; p. 349
Main Authors:	Rodrigues, François, Coman, Tereza, Fouquet, Guillemette, Côté, Francine, Courtois, Geneviève, Trovati Maciel, Thiago, Hermine, Olivier
Format:	Journal Article
Language:	English
Published:	England 04-05-2023
Subjects:	Anemia, Hypochromic - genetics Anemia, Hypochromic - metabolism Expert Testimony Genetic Therapy Humans iron metabolism ineffective erythropoiesis GDF-11 hepcidin HSP70 Microcytic anemia
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Summary:	Microcytic anemias (MA) have frequent or rare etiologies. New discoveries in understanding and treatment of microcytic anemias need to be reviewed. Microcytic anemias with a focus on the most frequent causes and on monogenic diseases that are relevant for understanding biocellular mechanisms of MA. All treatments except gene therapy, with a focus on recent advances. PubMed search with references selected by expert opinion. As the genetic and cellular backgrounds of dyserythropoiesis will continue to be clarified, collaboration with bioengineering of treatments acting specifically at the protein domain level will continue to provide new therapies in hematology as well as oncology and neurology.
ISSN:	1747-4094
DOI:	10.1080/17474086.2023.2206556