Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location

• Published in: Oncotarget Vol. 9; no. 20; pp. 15302 - 15311
• Main Authors: Brandariz, Lorena, Arriba, María, García, Juan Luis, Cano, Juana María, Rueda, Daniel, Rubio, Eduardo, Rodríguez, Yolanda, Pérez, Jessica, Vivas, Alfredo, Sánchez, Carmen, Tapial, Sandra, Pena, Laura, García-Arranz, Mariano, García-Olmo, Damián, Urioste, Miguel, González-Sarmiento, Rogelio, Perea, José
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 16-03-2018
• Subjects: Research Paper; late-onset colorectal cancer; microsatellite instability; colon location; CpG island methylator phenotype; chromosomal instability
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.24502

Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC).
Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and
mutations, and an important mucinous component. Left colon cancers developed a higher number of polyps and multiple primary CRCs, showed the strongest familial component, and had better prognosis. Rectal cancers showed a predominantly sporadic phenotype, with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy number alterations (CNAs) greater than or equal to 50% were observed in this LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11, and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11.
and
were the only mutated genes showing differences according to the tumor location, mainly for right colon cancers.
We analyzed clinical and molecular characteristics of LOCRC at different tumor locations in order to determine if there are differential phenotypes related with the location in the colon.
Categorizing LOCRC according to tumor location appears to be an adequate first step to resolving the heterogeneity of this subset of CRC.