Metastatic solid tumours to the penis: a clinicopathologic evaluation of 109 cases from an international collaboration

• Published in: Histopathology Vol. 83; no. 1; pp. 31 - 39
• Main Authors: Nova-Camacho, Luiz M, Collins, Katrina, Trpkov, Kiril, Acosta, Andres M, Sangoi, Ankur R, Akgul, Mahmut, Chou, Angela, Polonia, Antonio, Rodrigues, Ângelo, Yilmaz, Asli, Perez-Montiel, Delia, Maclean, Fiona, Queipo Gutiérrez, Francisco Javier, Contreras, Félix, Wu, Howard H, Alvarado-Cabrero, Isabel, de Torres, Inés, Ruiz, Irune, Lobo, João, Prendeville, Susan, Manrique Celada, Manuel, Cheng, Liang, Galea, Laurence A, Hwang, Michael, Aron, Manju, García-Martos, María, Zalles, Nicole, Raspollini, Maria Rosaria, Williamson, Sean R, Ulbright, Thomas M, Panizo, Angel
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-07-2023
• Subjects: Adenocarcinoma; Biopsy; Diagnosis; Malignancy; Metastases; Metastasis; Nodules; Pain; Penis; Solid tumors; Tumors; Urinary bladder; penile; penis; metastasis; secondary tumours
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1111/his.14927

To elucidate the spectrum of metastatic tumours to the penis and their clinicopathologic features.
The databases and files of 22 pathology departments from eight countries on three continents were queried to identify metastatic solid tumours of the penis and to characterize their clinical and pathologic features.
We compiled a series of 109 cases of metastatic solid tumours that secondarily involved the penis. The mean patient age at diagnosis was 71 years (range, 7-94 years). Clinical presentation commonly included a penile nodule/mass (48/95; 51%) and localised pain (14/95; 15%). A prior history of malignancy was known in 92/104 (89%) patients. Diagnosis was made mainly on biopsy (82/109; 75%), or penectomy (21/109; 19%) specimens. The most common penile locations were the glans (45/98; 46%) and corpus cavernosum (39/98; 39%). The most frequent histologic type was adenocarcinoma (56%). Most primary carcinomas originated in the genitourinary (76/108; 70%) and gastrointestinal (20/108; 18%) tracts, including prostate (38/108; 35%), urinary bladder (27/108; 25%), and colon/rectum (18/108; 17%). Concurrent or prior extrapenile metastases were identified in 50/78 (64%) patients. Clinical follow-up (mean 22 months, range 0-171 months) was available for 87/109 (80%) patients, of whom 46 (53%) died of disease.
This is the largest study to date of metastatic solid tumours secondarily involving the penis. The most frequent primaries originated from the genitourinary and gastrointestinal tracts. Metastatic penile tumours usually presented with penile nodules/masses and pain, and they often occurred in the setting of advanced metastatic disease, portending poor clinical outcomes.