Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system

• Published in: Ukrainian biochemical journal Vol. 88; no. 4; pp. 29 - 39
• Main Authors: Shamelashvili, K L, Shtemenko, N I, Leus, L V, Babiy, S O, Shtemenko, O V
• Format: Journal Article
• Language: English
• Published: Ukraine National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 01-08-2016
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Antioxidants - chemical synthesis; Antioxidants - pharmacology; Carcinoma - blood; Carcinoma - drug therapy; Carcinoma - metabolism; Carcinoma - pathology; catalase; Catalase - blood; cisplatin; Coordination Complexes - chemical synthesis; Coordination Complexes - pharmacology; Enzyme Activation - drug effects; Erythrocytes - drug effects; Erythrocytes - enzymology; Glutathione Peroxidase - metabolism; Guerin’s carcinoma; Lipid Peroxidation - drug effects; Liposomes - administration & dosage; Nanoparticles - administration & dosage; Neoplasm Transplantation; Oxidative Stress - drug effects; Platinum - chemistry; Rats; Rats, Wistar; Rhenium - chemistry; Superoxide Dismutase - blood; Thiobarbituric Acid Reactive Substances - metabolism
• ISSN: 2409-4943; 2413-5003
• DOI: 10.15407/ubj88.04.029

Effects of the different modes of administration of dichlorotetra-μ-isobutyratodirhenium(ІІІ) – І – (in water solution, liposomes, nanoliposomes and together with cisplatin – in the rhenium-platinum system) on the intensity of lipid peroxidation (LP) in blood plasma and the activity of the erythrocyte antioxidant enzymes were investigated on the model of tumor growth. A decrease in the concentration of TBA-active substances caused by dirhenium compounds was shown to be independent of the administration mode and the extent of the tumor growth inhibition. I was four-times more effective in inhibition of the LP burst than any known antioxidant. I induced the increasing activity of erythrocyte superoxide dismutase and decreasing activity of catalase. In vitro experiments with native superoxide dismutase, the interaction of І with following activation of the active center of the enzyme was confirmed and the superoxide dismutase activity of І was shown, that may contribute to the enhancement of the enzyme activity in vivo. The cluster rhenium compounds may be promising nontoxic potent antioxidants capable of deactivating superoxide radicals.