Pregnancy‐associated atypical hemolytic uremic syndrome. Case report

• Published in: The journal of obstetrics and gynaecology research Vol. 50; no. 7; pp. 1268 - 1272
• Main Authors: Barrera‐Hoffmann, Christopher, Mariaca‐Ortíz, Yadira, Ruiz‐Villa, Josué Giovani, Cuevas‐Cruz, Lesllie Eugenia, López‐Mendoza, María del Rosario, Briones‐Garduño, Jesús Carlos
• Format: Journal Article
• Language: English
• Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01-07-2024; Wiley Subscription Services, Inc
• Subjects: atypical hemolytic uremic syndrome; Fetuses; Hemolytic anemia; Hemolytic uremic syndrome; Pregnancy; Puerperium; Renal function; Septic shock; Thrombocytopenia; Thrombotic microangiopathy; atypical hemolytic uremic syndrome; pregnancy; thrombotic microangiopathy
• ISSN: 1341-8076; 1447-0756; 1447-0756
• DOI: 10.1111/jog.15958

Pregnancy‐associated atypical hemolytic uremic syndrome (P‐aHUS) is a rare disease. There are only few reports in the literature, and most are in the puerperium period. It is a thrombotic microangiopathy (TMA) characterized for microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction. We report the case of a pregnant patient at 26.3 gestation weeks, who developed clinical features of TMA, neurological alterations, and septic shock; then after fetus and placental delivery, no clinical improvement was observed; a diagnostic protocol was performed due to suspicion of P‐aHUS, showing improvement after the plasma exchange sessions and eculizumab. We present here a brief review of the case since it is an entity that needs to be suspected during pregnancy when TMA features and requires an immediate diagnosis to provide timely treatment.