Indicators of exchange of bile pigments under the action of ecopathogenic factors on the organism and correction with liposomes

• Published in: Ukrainian biochemical journal Vol. 86; no. 3; pp. 125 - 132
• Main Authors: Mel'nychuk, D O, Hryshchenko, V A, Vesel'skyĭ, S P
• Format: Journal Article
• Language: English; Ukrainian
• Published: Ukraine National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 01-05-2014
• Subjects: alpha-Tocopherol - administration & dosage; Animals; Antioxidants - administration & dosage; Bile Pigments - metabolism; Cadmium Chloride - toxicity; dietary supplements FLP-MD; exchange of bile pigments; Fatty Acids, Unsaturated - administration & dosage; Feces - chemistry; hepatocyte; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - radiation effects; ionizing radiation and cadmium chloride; Jejunum - drug effects; Jejunum - metabolism; Jejunum - radiation effects; Liposomes - administration & dosage; Liver - drug effects; Liver - metabolism; Liver - radiation effects; Male; Milk - chemistry; Phospholipids - administration & dosage; Phospholipids - isolation & purification; phospholipids milk; Radiation, Ionizing; Rats; Vitamin A - administration & dosage; Vitamin A - analogs & derivatives
• ISSN: 2409-4943; 2413-5003
• DOI: 10.15407/ubj86.03.125

High levels of anthropogenic impact on the environment requires a detailed study of the features of the influence of heavy metals and ionizing radiation on living organisms, and provides for the development and use of effective means of protecting the body from its negative influence. The purpose of the work was to study the characteristics of the exchange of bile pigments of rats under the action of ecopathogenic factors (ionizing radiation and cadmium) on the organism and the corrective properties of liposomes on the basis of milk phospholipids. An analysis of the chromatographic studies of bilirubin and derivatives (nonconjugated bilirubin, bilirubin sulfate, billirubin glucuronide, urobilin and stercobilin) in the whole blood, liver, jejunum contents and feces under the action on the animal organism of ecopathogenic factors (ionizing radiation and cadmium) indicate material violation of the exchange bile pigments that may be due to the destabilization of the structural and functional hot hepatocytes. Correction of the liposomal form of biologically active additive (BAA) FLP-MD is recommended; the latter is a mixture of phospholipids isolated from milk, with a mixture of unsaturated fatty acids (oleic, linoleic, linolenic) and antioxidants (alpha-tocopherol and retinol acetate). The additive components exhibit the reparative effect of the action in respect of the damaged membrane structures with simultaneous improving of cholepoietic and billiation liver function, and therefore contribute to the normalization of exchange og bile pigments in terms of action on the body ecopathogenic factors.