High‐risk adverse drug reactions: consideration of limited dialysis therapy for toxic epidermal necrolysis (TEN)

Toxic epidermal necrolysis (TEN) is a rare but often lethal drug reaction involving the skin. Treatment is often centered around suppurative care, and the mortality rate remains unacceptably high, although the clinical and epidemiological features of TEN have been well documented for decades. Recent...

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Bibliographic Details
Published in:	International journal of dermatology Vol. 63; no. 1; pp. 5 - 9
Main Authors:	Xie, Guozhen, Pincelli, Thais, Hickson, LaTonya J., el‐Azhary, Rokea, Sokumbi, Olayemi
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-01-2024
Subjects:	Dermatology Dialysis Epidemiology Hemodialysis Patients Side effects Toxic epidermal necrolysis
Online Access:	Get full text
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Summary:	Toxic epidermal necrolysis (TEN) is a rare but often lethal drug reaction involving the skin. Treatment is often centered around suppurative care, and the mortality rate remains unacceptably high, although the clinical and epidemiological features of TEN have been well documented for decades. Recent studies have placed an emphasis on certain medications in the pathophysiology of severe TEN, and our colleagues previously reported several cases of clinical improvement in TEN patients following hemodialysis. Here, we discuss the major considerations for initiating dialysis in TEN patients. By doing so, we hope to encourage others to explore this potential avenue for treating TEN, one of the most serious medical emergencies in the field of dermatology.
Bibliography:	Conflict of interest: None. Funding source: None. SourceType-Other Sources-1 ObjectType-News-1 content type line 66
ISSN:	0011-9059 1365-4632
DOI:	10.1111/ijd.16882