The effects of dietary macronutrient composition on resting energy expenditure following active weight loss: A systematic review and meta‐analysis

• Published in: Obesity reviews Vol. 25; no. 8; pp. e13760 - n/a
• Main Authors: Ho, Dang Khanh Ngan, Liao, Yu Chi, Mayasari, Noor Rohmah, Chien, Mu‐Ming, Chung, Mei, Bai, Chyi‐Huey, Huang, Ya‐Li, Chen, Yang‐Ching, Tseng, Sung‐Hui, Chang, Chun‐Chao, Chiu, Wan‐Chun, Sangopas, Patchara, Tseng, Hsiang‐Tung, Kao, Jing Wen, Ngu, Yi Jing, Chang, Jung‐Su
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-08-2024
• Subjects: Basal Metabolism - physiology; calorie restriction; Carbohydrates; Composition; Diet, Reducing; Dietary Carbohydrates; Dietary Fats - administration & dosage; Dietary Proteins - administration & dosage; Energy expenditure; Energy Intake - physiology; Energy Metabolism - physiology; High fat diet; High protein diet; Humans; low‐carbohydrate and low‐fat diet; Meta-analysis; Metabolic response; Nutrients; Obesity - diet therapy; Obesity - metabolism; Proteins; Regression analysis; resting energy expenditure; Statistical analysis; Systematic review; Weight; Weight loss; Weight Loss - physiology; resting energy expenditure; calorie restriction; low‐carbohydrate and low‐fat diet
• ISSN: 1467-7881; 1467-789X; 1467-789X
• DOI: 10.1111/obr.13760

Summary
A systematic review and meta‐analysis was conducted to evaluate the relative effectiveness of different dietary macronutrient patterns on changes in resting energy expenditure (REE) in relation to weight loss, categorized as minimal (<5%) and moderate to high (>5%). Changes in REE were assessed using a DerSimonian and Laird random‐effects meta‐analysis. A diet lower in carbohydrates (CHO) or higher in fat and protein was associated with smaller reductions in REE, with these trends being more pronounced among participants who experienced moderate to high weight loss. Adjusted meta‐regression analysis indicated that, within the participants who experienced moderate to high weight loss, each 1% increase in CHO intake was associated with a reduction of 2.30 kcal/day in REE (95% CI: −4.11 to −0.47, p = 0.013). In contrast, a 1% increase in protein and fat intake was correlated with an increase in REE by 3.00 (95% confidence interval [CI] [1.02, 5.07], p = 0.003) and 0.5 (95% CI [−2.43, 3.41], p = 0.740) kcal/day, respectively. No significant associations were found among participants who experienced minimal weight loss. These findings indicate that, under a caloric deficit, the impact of dietary macronutrient composition on REE may vary depending on the degree of weight loss and individual metabolic responses.