Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets

In the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (r...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 249; no. 1; p. R3
Main Authors:	Bountra, C, Bunce, K, Dale, T, Gardner, C, Jordan, C, Twissell, D, Ward, P
Format:	Journal Article
Language:	English
Published:	Netherlands 02-11-1993
Subjects:	Animals Ferrets Male Neurokinin A - antagonists & inhibitors Piperidines - administration & dosage Piperidines - therapeutic use Stereoisomerism Substance P - metabolism Vomiting - chemically induced Vomiting - drug therapy
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Summary:	In the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (racemic CP-99,994) in the ferret. Racemic CP-99,994 was effective against a range of emetogens, comprising cytotoxic drugs, radiation, morphine, ipecacuanha and copper sulphate.
ISSN:	0014-2999
DOI:	10.1016/0014-2999(93)90673-6