A case of large cell CNS lymphoma associated with a systemic small cell lymphocytic lymphoma

• Published in: Journal of neuro-oncology Vol. 9; no. 2; pp. 171 - 175
• Main Authors: WEISSMAN, D. E, KUECK, B. D, MERKOW, A. B
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01-10-1990
• Subjects: Biological and medical sciences; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - drug therapy; Brain Neoplasms - pathology; Female; Follow-Up Studies; Hematologic and hematopoietic diseases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Large B-Cell, Diffuse - diagnostic imaging; Lymphoma, Large B-Cell, Diffuse - pathology; Medical sciences; Middle Aged; Neoplasms, Multiple Primary - diagnostic imaging; Neoplasms, Multiple Primary - drug therapy; Neoplasms, Multiple Primary - pathology; Tomography, X-Ray Computed; Human; Intracranial; Nervous system diseases; Pathogenesis; Central nervous system; Malignant hemopathy; Hemopathy; B-Lymphocyte; Non Hodgkin lymphoma; Immune deficiency; Lymphoma; Case study; Concomitant disease; Evolution; Tumor
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1007/BF02427839

A case is reported of a 59 y/o woman with a large cell CNS lymphoma and a small cell lymphocytic lymphoma in the bone marrow. The brain tumor underwent spontaneous regression and subsequent regrowth while there was slow progression of the systemic small cell lymphoma. The CNS lymphoma regressed rapidly following treatment with prednisone and cyclophosphamide. We hypothesize that the small cell lymphoma in this patient may represent an underlying immunodeficiency disorder.