Ivermectin binds avidly to plasma proteins

Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy indivi...

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Bibliographic Details
Published in:	European journal of clinical pharmacology Vol. 39; no. 6; pp. 607 - 608
Main Authors:	KLOTZ, U, OGBUOKIRI, J. E, OKONKWO, P. O
Format:	Journal Article
Language:	English
Published:	Heidelberg Springer 01-01-1990 Berlin
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Blood Proteins - metabolism Chromatography, High Pressure Liquid - methods Humans Ivermectin - blood Ivermectin - pharmacokinetics Medical sciences Pharmacology. Drug treatments Protein Binding Human Proteins Biological fixation Parasiticid HPLC chromatography Normal Pharmacokinetics Blood plasma
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Summary:	Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2 +/- 4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF00316107