Effects of Aging on Intrinsic Protein Disorder in Human Lenses and Zonules
This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from...
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| Published in: | Cell biochemistry and biophysics Vol. 82; no. 4; pp. 3667 - 3679 |
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01-12-2024
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| Abstract | This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from the lens and zonule proteomes previously published by Wang et al. and De Maria et al. Bioinformatics tools, including a composition profiler and a rapid intrinsic disorder analysis online tool, were used to conduct a comparative analysis of protein disorder. Statistical tests such as ANOVA, Tukey’s HSD, and chi-squared tests were applied to evaluate differences between groups. The study revealed distinct amino acid compositions for each proteome, showing a direct correlation between aging and increased protein disorder in the zonular proteomes, whereas the lens proteomes exhibited the opposite trend. Findings suggest that age-related changes in intrinsic protein disorder within the lens and zonule proteomes may be linked to structural transformations in these tissues. Understanding how protein disorder evolves with age could enhance knowledge of the molecular basis for age-related conditions such as cataracts and pseudoexfoliation, potentially leading to better therapeutic strategies. |
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| AbstractList | This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from the lens and zonule proteomes previously published by Wang et al. and De Maria et al. Bioinformatics tools, including a composition profiler and a rapid intrinsic disorder analysis online tool, were used to conduct a comparative analysis of protein disorder. Statistical tests such as ANOVA, Tukey’s HSD, and chi-squared tests were applied to evaluate differences between groups. The study revealed distinct amino acid compositions for each proteome, showing a direct correlation between aging and increased protein disorder in the zonular proteomes, whereas the lens proteomes exhibited the opposite trend. Findings suggest that age-related changes in intrinsic protein disorder within the lens and zonule proteomes may be linked to structural transformations in these tissues. Understanding how protein disorder evolves with age could enhance knowledge of the molecular basis for age-related conditions such as cataracts and pseudoexfoliation, potentially leading to better therapeutic strategies. This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from the lens and zonule proteomes previously published by Wang et al. and De Maria et al. Bioinformatics tools, including a composition profiler and a rapid intrinsic disorder analysis online tool, were used to conduct a comparative analysis of protein disorder. Statistical tests such as ANOVA, Tukey's HSD, and chi-squared tests were applied to evaluate differences between groups. The study revealed distinct amino acid compositions for each proteome, showing a direct correlation between aging and increased protein disorder in the zonular proteomes, whereas the lens proteomes exhibited the opposite trend. Findings suggest that age-related changes in intrinsic protein disorder within the lens and zonule proteomes may be linked to structural transformations in these tissues. Understanding how protein disorder evolves with age could enhance knowledge of the molecular basis for age-related conditions such as cataracts and pseudoexfoliation, potentially leading to better therapeutic strategies.This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from the lens and zonule proteomes previously published by Wang et al. and De Maria et al. Bioinformatics tools, including a composition profiler and a rapid intrinsic disorder analysis online tool, were used to conduct a comparative analysis of protein disorder. Statistical tests such as ANOVA, Tukey's HSD, and chi-squared tests were applied to evaluate differences between groups. The study revealed distinct amino acid compositions for each proteome, showing a direct correlation between aging and increased protein disorder in the zonular proteomes, whereas the lens proteomes exhibited the opposite trend. Findings suggest that age-related changes in intrinsic protein disorder within the lens and zonule proteomes may be linked to structural transformations in these tissues. Understanding how protein disorder evolves with age could enhance knowledge of the molecular basis for age-related conditions such as cataracts and pseudoexfoliation, potentially leading to better therapeutic strategies. |
| Author | Greenfield, Jason A. Karp, Carol L. Gonzalez, David J. Taylor Uversky, Vladimir N. Kim, Colin K. Gibbons, Allister G. Djulbegovic, Mak B. Antonietti, Michael |
| Author_xml | – sequence: 1 givenname: Michael surname: Antonietti fullname: Antonietti, Michael organization: Bascom Palmer Eye Institute, University of Miami – sequence: 2 givenname: Colin K. surname: Kim fullname: Kim, Colin K. organization: Bascom Palmer Eye Institute, University of Miami – sequence: 3 givenname: Mak B. surname: Djulbegovic fullname: Djulbegovic, Mak B. organization: Wills Eye Hospital, Thomas Jefferson University Hospital – sequence: 4 givenname: David J. Taylor surname: Gonzalez fullname: Gonzalez, David J. Taylor organization: Bascom Palmer Eye Institute, University of Miami – sequence: 5 givenname: Jason A. surname: Greenfield fullname: Greenfield, Jason A. organization: Bascom Palmer Eye Institute, University of Miami – sequence: 6 givenname: Vladimir N. surname: Uversky fullname: Uversky, Vladimir N. organization: Department of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida – sequence: 7 givenname: Allister G. surname: Gibbons fullname: Gibbons, Allister G. organization: Bascom Palmer Eye Institute, University of Miami – sequence: 8 givenname: Carol L. surname: Karp fullname: Karp, Carol L. email: ckarp@med.miami.edu organization: Bascom Palmer Eye Institute, University of Miami |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39117985$$D View this record in MEDLINE/PubMed |
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| Keywords | Zonules Lens proteomics Intrinsically disordered proteins bioinformatics |
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| References | Wistow, Piatigorsky (CR15) 1988; 57 De Maria, Wilmarth, David, Bassnett (CR8) 2017; 58 Ayyadevara, Ganne, Balasubramaniam, Shmookler Reis (CR22) 2022; 37 Antonietti, Gonzalez, Djulbegovic, Gamerio, Uversky, Sridhar, Karp (CR3) 2024; 267 Muranov, Ostrovsky (CR12) 2022; 87 Michael, Bron (CR5) 2011; 366 Andley (CR17) 2007; 26 Uversky (CR20) 2013; 22 Peng, Vucetic, Radivojac, Brown, Dunker, Obradovic (CR26) 2005; 3 Fan, Xiaoqin, Potts, Strauch, Nemet, Monnier (CR34) 2011; 17 Glasser, Campbell (CR13) 1999; 39 Bassnett (CR11) 2009; 88 Bassnett (CR18) 2021; 82 Santofimia-Castano, Rizzuti, Xia, Abian, Peng, Velazquez-Campoy, Neira, Iovanna (CR21) 2020; 77 Heys, Cram, Truscott (CR14) 2004; 10 CR30 Dikopf, Chow, Mieler, Tu (CR41) 2013; 156 Necci, Piovesan, Tosatto (CR27) 2021; 18 Shi, Tu, De Maria, Mecham, Bassnett (CR39) 2013; 54 Katz, Karpecki, Dorca, Chiva-Razavi, Floyd, Barnes, Wuttke, Donnenfeld (CR37) 2021; 15 Garner, Garner (CR38) 2016; 57 Taylor Gonzalez, Djulbegovic, Antonietti, Cordova, Dayhoff, Mattes, Galor, Uversky, Karp (CR2) 2023; 64 Hernandez-Zimbron, Gulias-Canizo, Golzarri, Martinez-Baez, Quiroz-Mercado, Gonzalez-Salinas (CR4) 2017; 2017 Moreau, King (CR6) 2012; 18 Xue, Oldfield, Dunker, Uversky (CR31) 2009; 583 Djulbegovic, Uversky (CR1) 2022; 29 Vazquez, Lee (CR7) 2014; 54 Dayhoff, Uversky (CR25) 2022; 31 Vacic, Uversky, Dunker, Lonardi (CR24) 2007; 8 Rankenberg, Rakete, Wagner, Patnaik, Henning, Lynch, Glomb, Nagaraj (CR36) 2021; 210 Consortium (CR23) 2022; 51 Thomson, Singh, Eckersley, Cain, Sherratt, Baldock (CR33) 2019; 89 Nankivil, Maceo Heilman, Durkee, Manns, Ehrmann, Kelly, Arrieta-Quintero, Parel (CR40) 2015; 56 Ruan, Liu, Luo, Liu (CR10) 2020; 5 Ma, Gao, Tong, Li, Chen (CR35) 2017; 97 Wang, Han, David, Schey (CR9) 2013; 54 Djulbegovic, Uversky (CR29) 2022; 29 Djulbegovic, Taylor, Antonietti, Cordova, Dayhoff, Uversky, Galor, Karp (CR28) 2023; 64 Hejtmancik, Shiels (CR16) 2015; 134 Chakrabarti, Chakravarty (CR19) 2022; 283 Piha-Gossack, Sossin, Reinhardt (CR32) 2012; 7 M Necci (1455_CR27) 2021; 18 X Fan (1455_CR34) 2011; 17 DJ Taylor Gonzalez (1455_CR2) 2023; 64 1455_CR30 GW Dayhoff (1455_CR25) 2022; 31 A De Maria (1455_CR8) 2017; 58 VN Uversky (1455_CR20) 2013; 22 J Rankenberg (1455_CR36) 2021; 210 UP Andley (1455_CR17) 2007; 26 LE Vazquez (1455_CR7) 2014; 54 B Xue (1455_CR31) 2009; 583 KL Moreau (1455_CR6) 2012; 18 GJ Wistow (1455_CR15) 1988; 57 M Antonietti (1455_CR3) 2024; 267 S Bassnett (1455_CR11) 2009; 88 KO Muranov (1455_CR12) 2022; 87 P Santofimia-Castano (1455_CR21) 2020; 77 TU Consortium (1455_CR23) 2022; 51 S Ayyadevara (1455_CR22) 2022; 37 XJ Ma (1455_CR35) 2017; 97 A Piha-Gossack (1455_CR32) 2012; 7 X Ruan (1455_CR10) 2020; 5 J Thomson (1455_CR33) 2019; 89 KR Heys (1455_CR14) 2004; 10 P Chakrabarti (1455_CR19) 2022; 283 V Vacic (1455_CR24) 2007; 8 M Djulbegovic (1455_CR1) 2022; 29 WH Garner (1455_CR38) 2016; 57 R Michael (1455_CR5) 2011; 366 Y Shi (1455_CR39) 2013; 54 Z Wang (1455_CR9) 2013; 54 M Djulbegovic (1455_CR29) 2022; 29 JA Katz (1455_CR37) 2021; 15 S Bassnett (1455_CR18) 2021; 82 MB Djulbegovic (1455_CR28) 2023; 64 D Nankivil (1455_CR40) 2015; 56 LF Hernandez-Zimbron (1455_CR4) 2017; 2017 A Glasser (1455_CR13) 1999; 39 K Peng (1455_CR26) 2005; 3 JF Hejtmancik (1455_CR16) 2015; 134 MS Dikopf (1455_CR41) 2013; 156 |
| References_xml | – volume: 26 start-page: 78 issue: 1 year: 2007 end-page: 98 ident: CR17 article-title: Crystallins in the eye: Function and pathology publication-title: Progress in Retinal and Eye Research doi: 10.1016/j.preteyeres.2006.10.003 contributor: fullname: Andley – volume: 283 year: 2022 ident: CR19 article-title: Intrinsically disordered proteins/regions and insight into their biomolecular interactions publication-title: Biophysical Chemistry doi: 10.1016/j.bpc.2022.106769 contributor: fullname: Chakravarty – volume: 57 start-page: 479 year: 1988 end-page: 504 ident: CR15 article-title: Lens crystallins: the evolution and expression of proteins for a highly specialized tissue publication-title: Annual Review of Biochemistry doi: 10.1146/annurev.bi.57.070188.002403 contributor: fullname: Piatigorsky – volume: 64 start-page: 187 issue: 8 year: 2023 end-page: 187 ident: CR28 article-title: Intrinsic disorder and the human tear film proteome publication-title: Investigative Ophthalmology & Visual Science contributor: fullname: Karp – volume: 64 start-page: 14 issue: 11 year: 2023 ident: CR2 article-title: Intrinsic disorder in the human tear proteome publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.64.11.14 contributor: fullname: Karp – volume: 2017 year: 2017 ident: CR4 article-title: Molecular age-related changes in the anterior segment of the eye publication-title: British Journal of Ophthalmology doi: 10.1155/2017/1295132 contributor: fullname: Gonzalez-Salinas – volume: 18 start-page: 273 issue: 5 year: 2012 end-page: 282 ident: CR6 article-title: Protein misfolding and aggregation in cataract disease and prospects for prevention publication-title: Trends in Molecular Medicine doi: 10.1016/j.molmed.2012.03.005 contributor: fullname: King – volume: 18 start-page: 472 issue: 5 year: 2021 end-page: 481 ident: CR27 article-title: Critical assessment of protein intrinsic disorder prediction publication-title: Nature Methods doi: 10.1038/s41592-021-01117-3 contributor: fullname: Tosatto – volume: 210 year: 2021 ident: CR36 article-title: Advanced glycation end products in human diabetic lens capsules publication-title: Experimental Eye Research doi: 10.1016/j.exer.2021.108704 contributor: fullname: Nagaraj – ident: CR30 – volume: 29 start-page: 101202 year: 2022 ident: CR29 article-title: The aqueous humor proteome is intrinsically disordered publication-title: Biochemistry and Biophysics Reports doi: 10.1016/j.bbrep.2022.101202 contributor: fullname: Uversky – volume: 7 start-page: e33560 issue: 3 year: 2012 ident: CR32 article-title: The evolution of extracellular fibrillins and their functional domains publication-title: PLoS One doi: 10.1371/journal.pone.0033560 contributor: fullname: Reinhardt – volume: 54 start-page: 1135 issue: 2 year: 2013 end-page: 1143 ident: CR9 article-title: Proteomics and phosphoproteomics analysis of human lens fiber cell membranes publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.12-11168 contributor: fullname: Schey – volume: 134 start-page: 119 year: 2015 end-page: 127 ident: CR16 article-title: Overview of the lens publication-title: Progress in Molecular Biology and Translational Science doi: 10.1016/bs.pmbts.2015.04.006 contributor: fullname: Shiels – volume: 97 start-page: 5168 issue: 15 year: 2017 end-page: 5175 ident: CR35 article-title: Tracking the behavior of Maillard browning in lysine/arginine-sugar model systems under high hydrostatic pressure publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.8398 contributor: fullname: Chen – volume: 58 start-page: 573 issue: 1 year: 2017 end-page: 585 ident: CR8 article-title: Proteomic analysis of the bovine and human ciliary zonule publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.16-20866 contributor: fullname: Bassnett – volume: 54 start-page: 2504 issue: 4 year: 2013 end-page: 2515 ident: CR39 article-title: Development, composition, and structural arrangements of the ciliary zonule of the mouse publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.13-11619 contributor: fullname: Bassnett – volume: 37 start-page: 147 issue: 1 year: 2022 end-page: 152 ident: CR22 article-title: Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration publication-title: Metabolic Brain Disease doi: 10.1007/s11011-021-00791-8 contributor: fullname: Shmookler Reis – volume: 57 start-page: 2851 issue: 6 year: 2016 end-page: 2863 ident: CR38 article-title: Protein disulfide levels and lens elasticity modulation: Applications for presbyopia publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.15-18413 contributor: fullname: Garner – volume: 156 start-page: 82 issue: 1 year: 2013 end-page: 88 ident: CR41 article-title: Cataract extraction outcomes and the prevalence of zonular insufficiency in retinitis pigmentosa publication-title: American Journal of Ophthalmology doi: 10.1016/j.ajo.2013.02.002 contributor: fullname: Tu – volume: 77 start-page: 1695 issue: 9 year: 2020 end-page: 1707 ident: CR21 article-title: Targeting intrinsically disordered proteins involved in cancer publication-title: Cellular and Molecular Life Sciences doi: 10.1007/s00018-019-03347-3 contributor: fullname: Iovanna – volume: 31 issue: 12 year: 2022 ident: CR25 article-title: Rapid prediction and analysis of protein intrinsic disorder publication-title: Protein Science doi: 10.1002/pro.4496 contributor: fullname: Uversky – volume: 22 start-page: 693 issue: 6 year: 2013 end-page: 724 ident: CR20 article-title: A decade and a half of protein intrinsic disorder: biology still waits for physics publication-title: Protein Science doi: 10.1002/pro.2261 contributor: fullname: Uversky – volume: 88 start-page: 133 issue: 2 year: 2009 end-page: 139 ident: CR11 article-title: On the mechanism of organelle degradation in the vertebrate lens publication-title: Experimental Eye Research doi: 10.1016/j.exer.2008.08.017 contributor: fullname: Bassnett – volume: 89 start-page: 109 year: 2019 end-page: 117 ident: CR33 article-title: Fibrillin microfibrils and elastic fibre proteins: Functional interactions and extracellular regulation of growth factors publication-title: Seminars in Cell and Developmental Biology doi: 10.1016/j.semcdb.2018.07.016 contributor: fullname: Baldock – volume: 17 start-page: 2221 year: 2011 end-page: 2227 ident: CR34 article-title: Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice publication-title: Molecular Vision contributor: fullname: Monnier – volume: 87 start-page: 106 issue: 2 year: 2022 end-page: 120 ident: CR12 article-title: Biochemistry of eye lens in the norm and in cataractogenesis publication-title: Biochemistry (Moscow) doi: 10.1134/S0006297922020031 contributor: fullname: Ostrovsky – volume: 15 start-page: 2167 year: 2021 end-page: 2178 ident: CR37 article-title: Presbyopia - A review of current treatment options and emerging therapies publication-title: Clinical Ophthalmology doi: 10.2147/OPTH.S259011 contributor: fullname: Donnenfeld – volume: 82 year: 2021 ident: CR18 article-title: Zinn’s zonule publication-title: Progress in Retinal and Eye Research doi: 10.1016/j.preteyeres.2020.100902 contributor: fullname: Bassnett – volume: 366 start-page: 1278 issue: 1568 year: 2011 end-page: 1292 ident: CR5 article-title: The ageing lens and cataract: a model of normal and pathological ageing publication-title: Philosophical Transactions of the Royal Society B: Biological Sciences doi: 10.1098/rstb.2010.0300 contributor: fullname: Bron – volume: 583 start-page: 1469 issue: 9 year: 2009 end-page: 1474 ident: CR31 article-title: CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions publication-title: FEBS Letters doi: 10.1016/j.febslet.2009.03.070 contributor: fullname: Uversky – volume: 29 year: 2022 ident: CR1 article-title: The aqueous humor proteome is intrinsically disordered publication-title: Biochemistry and Biophysics Reports doi: 10.1016/j.bbrep.2022.101202 contributor: fullname: Uversky – volume: 54 start-page: 1 issue: 4 year: 2014 end-page: 13 ident: CR7 article-title: Genomic and proteomic pathophysiology of pseudoexfoliation glaucoma publication-title: International Ophthalmology Clinics doi: 10.1097/IIO.0000000000000047 contributor: fullname: Lee – volume: 39 start-page: 1991 issue: 11 year: 1999 end-page: 2015 ident: CR13 article-title: Biometric, optical and physical changes in the isolated human crystalline lens with age in relation to presbyopia publication-title: Vision Research doi: 10.1016/s0042-6989(98)00283-1 contributor: fullname: Campbell – volume: 51 start-page: D523 issue: D1 year: 2022 end-page: D531 ident: CR23 article-title: UniProt: the Universal Protein Knowledgebase in 2023 publication-title: Nucleic Acids Research doi: 10.1093/nar/gkac1052 contributor: fullname: Consortium – volume: 10 start-page: 956 year: 2004 end-page: 963 ident: CR14 article-title: Massive increase in the stiffness of the human lens nucleus with age: the basis for presbyopia? publication-title: Molecular Vision contributor: fullname: Truscott – volume: 8 year: 2007 ident: CR24 article-title: Composition Profiler: a tool for discovery and visualization of amino acid composition differences publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-8-211 contributor: fullname: Lonardi – volume: 56 start-page: 1751 issue: 3 year: 2015 end-page: 1760 ident: CR40 article-title: The zonules selectively alter the shape of the lens during accommodation based on the location of their anchorage points publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.14-16082 contributor: fullname: Parel – volume: 3 start-page: 35 issue: 1 year: 2005 end-page: 60 ident: CR26 article-title: Optimizing long intrinsic disorder predictors with protein evolutionary information publication-title: Journal of Bioinformatics and Computational Biology doi: 10.1142/s0219720005000886 contributor: fullname: Obradovic – volume: 5 start-page: e000459 issue: 1 year: 2020 ident: CR10 article-title: The structure of the lens and its associations with the visual quality publication-title: BMJ Open Ophthalmology doi: 10.1136/bmjophth-2020-000459 contributor: fullname: Liu – volume: 267 start-page: 131274 year: 2024 ident: CR3 article-title: Intrinsic disorder in the human vitreous proteome publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2024.131274 contributor: fullname: Karp – volume: 82 year: 2021 ident: 1455_CR18 publication-title: Progress in Retinal and Eye Research doi: 10.1016/j.preteyeres.2020.100902 contributor: fullname: S Bassnett – volume: 22 start-page: 693 issue: 6 year: 2013 ident: 1455_CR20 publication-title: Protein Science doi: 10.1002/pro.2261 contributor: fullname: VN Uversky – volume: 583 start-page: 1469 issue: 9 year: 2009 ident: 1455_CR31 publication-title: FEBS Letters doi: 10.1016/j.febslet.2009.03.070 contributor: fullname: B Xue – volume: 134 start-page: 119 year: 2015 ident: 1455_CR16 publication-title: Progress in Molecular Biology and Translational Science doi: 10.1016/bs.pmbts.2015.04.006 contributor: fullname: JF Hejtmancik – volume: 3 start-page: 35 issue: 1 year: 2005 ident: 1455_CR26 publication-title: Journal of Bioinformatics and Computational Biology doi: 10.1142/s0219720005000886 contributor: fullname: K Peng – volume: 89 start-page: 109 year: 2019 ident: 1455_CR33 publication-title: Seminars in Cell and Developmental Biology doi: 10.1016/j.semcdb.2018.07.016 contributor: fullname: J Thomson – volume: 8 year: 2007 ident: 1455_CR24 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-8-211 contributor: fullname: V Vacic – volume: 283 year: 2022 ident: 1455_CR19 publication-title: Biophysical Chemistry doi: 10.1016/j.bpc.2022.106769 contributor: fullname: P Chakrabarti – volume: 77 start-page: 1695 issue: 9 year: 2020 ident: 1455_CR21 publication-title: Cellular and Molecular Life Sciences doi: 10.1007/s00018-019-03347-3 contributor: fullname: P Santofimia-Castano – volume: 64 start-page: 187 issue: 8 year: 2023 ident: 1455_CR28 publication-title: Investigative Ophthalmology & Visual Science contributor: fullname: MB Djulbegovic – volume: 210 year: 2021 ident: 1455_CR36 publication-title: Experimental Eye Research doi: 10.1016/j.exer.2021.108704 contributor: fullname: J Rankenberg – volume: 54 start-page: 1135 issue: 2 year: 2013 ident: 1455_CR9 publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.12-11168 contributor: fullname: Z Wang – volume: 7 start-page: e33560 issue: 3 year: 2012 ident: 1455_CR32 publication-title: PLoS One doi: 10.1371/journal.pone.0033560 contributor: fullname: A Piha-Gossack – volume: 17 start-page: 2221 year: 2011 ident: 1455_CR34 publication-title: Molecular Vision contributor: fullname: X Fan – ident: 1455_CR30 – volume: 97 start-page: 5168 issue: 15 year: 2017 ident: 1455_CR35 publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.8398 contributor: fullname: XJ Ma – volume: 267 start-page: 131274 year: 2024 ident: 1455_CR3 publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2024.131274 contributor: fullname: M Antonietti – volume: 10 start-page: 956 year: 2004 ident: 1455_CR14 publication-title: Molecular Vision contributor: fullname: KR Heys – volume: 87 start-page: 106 issue: 2 year: 2022 ident: 1455_CR12 publication-title: Biochemistry (Moscow) doi: 10.1134/S0006297922020031 contributor: fullname: KO Muranov – volume: 56 start-page: 1751 issue: 3 year: 2015 ident: 1455_CR40 publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.14-16082 contributor: fullname: D Nankivil – volume: 15 start-page: 2167 year: 2021 ident: 1455_CR37 publication-title: Clinical Ophthalmology doi: 10.2147/OPTH.S259011 contributor: fullname: JA Katz – volume: 54 start-page: 2504 issue: 4 year: 2013 ident: 1455_CR39 publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.13-11619 contributor: fullname: Y Shi – volume: 58 start-page: 573 issue: 1 year: 2017 ident: 1455_CR8 publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.16-20866 contributor: fullname: A De Maria – volume: 31 issue: 12 year: 2022 ident: 1455_CR25 publication-title: Protein Science doi: 10.1002/pro.4496 contributor: fullname: GW Dayhoff – volume: 51 start-page: D523 issue: D1 year: 2022 ident: 1455_CR23 publication-title: Nucleic Acids Research doi: 10.1093/nar/gkac1052 contributor: fullname: TU Consortium – volume: 88 start-page: 133 issue: 2 year: 2009 ident: 1455_CR11 publication-title: Experimental Eye Research doi: 10.1016/j.exer.2008.08.017 contributor: fullname: S Bassnett – volume: 57 start-page: 479 year: 1988 ident: 1455_CR15 publication-title: Annual Review of Biochemistry doi: 10.1146/annurev.bi.57.070188.002403 contributor: fullname: GJ Wistow – volume: 366 start-page: 1278 issue: 1568 year: 2011 ident: 1455_CR5 publication-title: Philosophical Transactions of the Royal Society B: Biological Sciences doi: 10.1098/rstb.2010.0300 contributor: fullname: R Michael – volume: 39 start-page: 1991 issue: 11 year: 1999 ident: 1455_CR13 publication-title: Vision Research doi: 10.1016/s0042-6989(98)00283-1 contributor: fullname: A Glasser – volume: 29 year: 2022 ident: 1455_CR1 publication-title: Biochemistry and Biophysics Reports doi: 10.1016/j.bbrep.2022.101202 contributor: fullname: M Djulbegovic – volume: 29 start-page: 101202 year: 2022 ident: 1455_CR29 publication-title: Biochemistry and Biophysics Reports doi: 10.1016/j.bbrep.2022.101202 contributor: fullname: M Djulbegovic – volume: 64 start-page: 14 issue: 11 year: 2023 ident: 1455_CR2 publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.64.11.14 contributor: fullname: DJ Taylor Gonzalez – volume: 18 start-page: 273 issue: 5 year: 2012 ident: 1455_CR6 publication-title: Trends in Molecular Medicine doi: 10.1016/j.molmed.2012.03.005 contributor: fullname: KL Moreau – volume: 54 start-page: 1 issue: 4 year: 2014 ident: 1455_CR7 publication-title: International Ophthalmology Clinics doi: 10.1097/IIO.0000000000000047 contributor: fullname: LE Vazquez – volume: 57 start-page: 2851 issue: 6 year: 2016 ident: 1455_CR38 publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.15-18413 contributor: fullname: WH Garner – volume: 26 start-page: 78 issue: 1 year: 2007 ident: 1455_CR17 publication-title: Progress in Retinal and Eye Research doi: 10.1016/j.preteyeres.2006.10.003 contributor: fullname: UP Andley – volume: 156 start-page: 82 issue: 1 year: 2013 ident: 1455_CR41 publication-title: American Journal of Ophthalmology doi: 10.1016/j.ajo.2013.02.002 contributor: fullname: MS Dikopf – volume: 18 start-page: 472 issue: 5 year: 2021 ident: 1455_CR27 publication-title: Nature Methods doi: 10.1038/s41592-021-01117-3 contributor: fullname: M Necci – volume: 37 start-page: 147 issue: 1 year: 2022 ident: 1455_CR22 publication-title: Metabolic Brain Disease doi: 10.1007/s11011-021-00791-8 contributor: fullname: S Ayyadevara – volume: 2017 year: 2017 ident: 1455_CR4 publication-title: British Journal of Ophthalmology doi: 10.1155/2017/1295132 contributor: fullname: LF Hernandez-Zimbron – volume: 5 start-page: e000459 issue: 1 year: 2020 ident: 1455_CR10 publication-title: BMJ Open Ophthalmology doi: 10.1136/bmjophth-2020-000459 contributor: fullname: X Ruan |
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| SubjectTerms | Aging Amino acid composition Amino acids Biochemistry Bioinformatics Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cataracts Cell Biology Chi-square test Comparative analysis Composition Lenses Life Sciences Original Paper Pharmaceuticals Pharmacology/Toxicology Protein composition Proteins Proteomes Proteomics Statistical analysis Statistical tests Variance analysis |
| Title | Effects of Aging on Intrinsic Protein Disorder in Human Lenses and Zonules |
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