Chronic toxicity test of garlic extract in rats

• Published in: Journal of toxicological sciences Vol. 9; no. 1; pp. 61 - 75
• Main Authors: SUMIYOSHI, Hiromichi, KANEZAWA, Atsushi, MASAMOTO, Koji, HARADA, Hiroshi, NAKAGAMI, Satoru, YOKOTA, Atsuko, NISHIKAWA, Midori, NAKAGAWA, Shizutoshi
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Japanese Society of Toxicology 1984; Japan Science and Technology Agency
• Subjects: Animals; Blood Chemical Analysis; Body Weight - drug effects; chronic toxicity test; Drinking - drug effects; Eating - drug effects; Female; Garlic - toxicity; Hematologic Tests; Kidney - drug effects; Liver - drug effects; Male; Organ Size - drug effects; Plant Extracts - toxicity; Plants, Medicinal; Rats; Rats, Inbred Strains
• ISSN: 0388-1350; 1880-3989
• DOI: 10.2131/jts.9.61

The influence of garlic extract on the chronic toxicity test were examined orally in Wistar rats for 6 months. There were no toxic symptoms due to garlic extract even at dose level of 2000 mg/kg for 5 times a week during 6 months. High dose of garlic extract did not inhibit the body weight gain, while the food consumption decreased slightly for the nutritional effects of it in both male and female rats. There were no significant differences in urinary, hematological and serological examinations compared each groups. In the histopathological findings, no toxic signs were observed on any of the tissues and organs examined.