Cross-Coupling Reaction of Chloropyridazines and Grignard Reagents with Nickel-phosphine Complexes : Alkylation and Arylation of Pyridazines

Cross-Coupling Reaction of Chloropyridazines and Grignard Reagents with Nickel-phosphine Complexes : Alkylation and Arylation of Pyridazines

Alkyl- and arylpyridazines have been prepared by cross-coupling reaction between chloropyridazines and Grignard reagents in the presence of nickel-phosphine complexes (as catalysts). Hitherto unaccessible naphthyl- and thienylpyridazines have been obtained.

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Bibliographic Details
Published in:Chemical & pharmaceutical bulletin Vol. 26; no. 8; pp. 2550 - 2554
Main Authors: OHSAWA, AKIO, ABE, YOSHIHITO, IGETA, HIROSHI
Format: Journal Article
Language:English
Published: The Pharmaceutical Society of Japan 1978
Subjects:
nickel-phosphine complex catalysis
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Description
Summary:Alkyl- and arylpyridazines have been prepared by cross-coupling reaction between chloropyridazines and Grignard reagents in the presence of nickel-phosphine complexes (as catalysts). Hitherto unaccessible naphthyl- and thienylpyridazines have been obtained.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.26.2550