Studies on high-dose chemotherapy of amygdalin in murine P388 lymphocytic leukaemia and P815 mast cell leukaemia

The anti-tumor activity of amygdalin (NSC 251222), commercially known as Laetrile, was investigated using P388 lymphocytic leukaemia and P815 mast-cell leukaemia in BDF1 mice. Doses varying from 200 mg/kg to 2,000 mg/kg were used following the days 1 and 5 and days 1, 5 and 9 schedules. Despite trea...

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Bibliographic Details
Published in:	Journal of cancer research and clinical oncology Vol. 109; no. 3; pp. 208 - 209
Main Authors:	CHITNIS, M. P, ADWANKAR, A. K, AMONKAR, A. J
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-01-1985
Subjects:	Amygdalin - administration & dosage Animals Antineoplastic agents Biological and medical sciences Chemotherapy Leukemia P388 - drug therapy Leukemia, Experimental - drug therapy Mast Cells Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments Antineoplastic agent Rodentia P388-Leukemia Malignant hemopathy Negative result Vertebrata Chemotherapy Experimental disease Mammalia Mouse Animal P815-Mastocytoma High dose Amygdalin
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Summary:	The anti-tumor activity of amygdalin (NSC 251222), commercially known as Laetrile, was investigated using P388 lymphocytic leukaemia and P815 mast-cell leukaemia in BDF1 mice. Doses varying from 200 mg/kg to 2,000 mg/kg were used following the days 1 and 5 and days 1, 5 and 9 schedules. Despite treatment with high doses of amygdalin there was no prolongation in the life-span of mice bearing either P388 or P815 tumor.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0171-5216 1432-1335
DOI:	10.1007/BF00390359