Long-term follow-up results of 175 patients with malignant glioma : importance of radical tumour resection and postoperative adjuvant therapy with interferon : ACNU and radiation

• Published in: Acta neurochirurgica Vol. 127; no. 1-2; pp. 55 - 59
• Main Authors: YOSHIDA, J, KAJITA, Y, WAKABAYASHI, T, SUGITA, K
• Format: Journal Article
• Language: English
• Published: Wien Springer 01-01-1994; New York, NY
• Subjects: Adolescent; Adult; Aged; Antineoplastic agents; Astrocytoma - drug therapy; Astrocytoma - mortality; Astrocytoma - radiotherapy; Astrocytoma - surgery; Biological and medical sciences; Brain Neoplasms - drug therapy; Brain Neoplasms - mortality; Brain Neoplasms - radiotherapy; Brain Neoplasms - surgery; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Combined treatments (chemotherapy of immunotherapy associated with an other treatment); Cranial Irradiation; Craniotomy; Female; Follow-Up Studies; Glioblastoma - drug therapy; Glioblastoma - mortality; Glioblastoma - radiotherapy; Glioblastoma - surgery; Humans; Infant; Interferon-beta - administration & dosage; Male; Medical sciences; Middle Aged; Nimustine - administration & dosage; Pharmacology. Drug treatments; Postoperative Complications - mortality; Radiotherapy, Adjuvant; Survival Rate; Antineoplastic agent; Human; Postoperative; Intracranial; Nervous system diseases; Nitrosoureas; Cytokine; Adjuvant treatment; Surgical resection; Malignant tumor; Radiotherapy; Survival; Malignant glioma; Chemotherapy; Treatment; Surgery; Central nervous system disease; Evolution; Interferon
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/BF01808547

We analysed long-term follow-up results of 175 patients with malignant glioma (110 glioblastoma and 65 anaplastic astrocytoma) treated under five different regimes during the past two decades. The factors of age (less than 40), histology (anaplastic astrocytoma) and type of adjuvant therapy (radiation and chemotherapy) contributed to long survival. The other important factor was the response to adjuvant therapy. Cases of gross total removal or complete response (CR) of a residual tumour to an adjuvant therapy showed a better prognosis. The three and five year survival rate was 42% and 24%, respectively. The highest CR ratio (23%) was seen in patients treated by intravenous injection of interferon and ACNU in addition to radiotherapy (IAR therapy).