Dose-response effects of 8-cyclopropyltheophylline on sleep and wakefulness in rats

• Published in: Psychopharmacologia Vol. 94; no. 3; pp. 417 - 420
• Main Authors: RADULOVACKI, M, VIRUS, R. M
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01-01-1988
• Subjects: Animals; Biological and medical sciences; Central Nervous System Stimulants - pharmacology; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Hypnotics. Sedatives; Male; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Inbred Strains; Sleep - drug effects; Sleep, REM - drug effects; Theophylline - analogs & derivatives; Theophylline - pharmacology; Wakefulness - drug effects; Intraperitoneal administration; Rat; Rodentia; Central nervous system; Electrophysiology; Electroencephalography; Dose activity relation; Vertebrata; Mammalia; Sleep; Insomnia; Animal; Electromyography; Xanthine derivatives; Sedative
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/BF00174700

The dose-response effects of the substituted xanthine 8-cyclopropyltheophylline (CPRT) on sleep and wakefulness (W) after intraperitoneal administration to rats were examined by means of simultaneous electroencephalographic (EEG) and electromyographic (EMG) recordings. Doses of 20 and 40 mg/kg CPRT increased W and decreased slow wave sleep (SWS) in rats, indicating CNS stimulant effects. The greatest CNS stimulation was produced by the lowest (20 mg/kg) dose of CPRT examined, which also increased the latency to SWS. In addition, the 20 mg/kg dose of CPRT also significantly decreased the amount of total sleep (TS), as compared to the vehicle group, during all time periods examined. In contrast, the 80 mg/kg dose of CPRT decreased W and increased both SWS and TS. However, this apparent hypnotic effect of the 80 mg/kg CPRT may be due to toxicity, since 80% of rats treated with this dose of the drug died within 48 h of injection.