Prevalence of aspirin resistance in patients with type II diabetes: a descriptive-analytical study

• Published in: International journal of clinical pharmacology and therapeutics Vol. 55; no. 6; pp. 493 - 497
• Main Authors: Eskandarian, Rahimeh, Razavi, Mohammadreza, Fattah, Abolfazal, Ghods, Kamran, Forozeshfard, Mohammad
• Format: Journal Article
• Language: English
• Published: Germany Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01-06-2017
• Subjects: Aged; Aspirin; Aspirin - therapeutic use; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Drug Resistance; Female; Humans; Logistic Models; Male; Middle Aged; Prevalence
• ISSN: 0946-1965
• DOI: 10.5414/CP202637

Aspirin resistance is one of the most important factors for arterial thrombotic events in diabetic patients. This study aimed to evaluate aspirin resistance in diabetic patients.
In this cross-sectional study, 180 patients who received 80 mg of aspirin daily for at least 10 days were studied, and their urinary 11-DH-TXB2 was measured. Those with 11-dehydro-thromboxane B2 above 1,500 pg/mg creatinine were considered aspirin resistant. Data with significance level of 5% were analyzed in SPSS-16.
The mean ± SD of patient age was 60.22 ± 9.59 years and 50% (n = 90) were male. BMI was normal in 29.4% of the patients (n = 53), the others were overweight or obese. Aspirin resistance was observed in 33 (18%) patients. The relationship between aspirin resistance and gender, age, and BMI was not significant (p > 0.05).
There is a high prevalence of aspirin resistance in diabetic patients and given that such patients are at risk of arterial thrombotic events, evaluation of aspirin resistance is suggested for those at a high risk of cardiovascular events or recurring events despite the use of aspirin.
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