Capture of recombinant ricin A chain by a bispecific anti-RTA : anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice

• Published in: Journal of cancer research and clinical oncology Vol. 118; no. 5; pp. 367 - 370
• Main Authors: PIMM, M. V, ROBINS, R. A, BALDWIN, R. W
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01-05-1992
• Subjects: Animals; Antibodies, Monoclonal - therapeutic use; Biological and medical sciences; Carcinoembryonic Antigen - analysis; Carcinoembryonic Antigen - immunology; Carcinoma - therapy; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunotoxins - administration & dosage; Medical sciences; Mice; Mice, Nude; Neoplasm Transplantation; Recombinant Proteins - immunology; Recombinant Proteins - therapeutic use; Ricin - immunology; Ricin - therapeutic use; Stomach Neoplasms - therapy; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transplantation, Heterologous; Tumors; Stomach; Intravenous administration; Carcinoma; Ricin; Rodentia; Malignant tumor; Monoclonal antibody; Heterotransplantation; Tissue; Carcinoembryonic antigen; Toxin; Vertebrata; Mammalia; Mouse; Animal; Distribution; Digestive diseases; Localization
• ISSN: 0171-5216; 1432-1335
• DOI: 10.1007/BF01294441

A bispecific antibody against carcinoembryonic antigen (CEA) and ricin A chain has been shown to localise in a CEA-producing human tumour xenograft. When labelled recombinant ricin A chain was subsequently injected there was uptake into tumours, indicating that this bispecific antibody can capture or carry toxin into tumour deposits.