The effects on memory of pipequaline, alone or in combination with diazepam

• Published in: Psychopharmacologia Vol. 95; no. 3; pp. 386 - 389
• Main Authors: EVES, F. F, CURRAN, H. V, SHINE, P, LADER, M. H
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01-01-1988
• Subjects: Adult; Anticonvulsants - pharmacology; Biological and medical sciences; Cognition - drug effects; Diazepam - pharmacology; Double-Blind Method; Emotions - drug effects; Female; Humans; Male; Medical sciences; Memory - drug effects; Neuropharmacology; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychomotor Performance - drug effects; Psychopharmacology; Quinolines - pharmacology; Human; Drug combination; Memory; Benzodiazepine receptor; Psychomotricity; Biological activity; Acquisition process; Tranquillizer; Benzodiazepine derivatives; Drug interaction; Agonist antagonist; Performance; Comparative study
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/BF00181953

Pipequaline (PK 8165) is a putative mixed agonist/antagonist at benzodiazepine receptors. The effects of pipequaline and diazepam on memory were assessed in 12 normal volunteers. Diazepam 10 mg or placebo was added to two doses of pipequaline, 50 and 150 mg, or to placebo in a double-blind crossover design. Diazepam produced impairments of episodic memory. In contrast, the effects of pipequaline were minor. Addition diazepam to pipequaline increased drowsiness and general lethargy, with a less marked effect occurring for the higher dose of pipequaline alone. Pipequaline did not antagonise any of the effects of diazepam.