Liraglutide-Induced Pancreatitis: A Case Report and Literature Review

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 4; p. e38263
• Main Authors: Javed, Hamna, Kogilathota Jagirdhar, Gowthami Sai, Kashyap, Rahul, Vekaria, Pratikkumar H
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 28-04-2023; Cureus
• Subjects: Abdomen; Alcohol; Antidiabetics; Blood; Case reports; Diabetes; Drug dosages; Endocrinology/Diabetes/Metabolism; Family/General Practice; Gallbladder; Gallbladder diseases; Gallstones; Insulin; Internal Medicine; Laboratories; Literature reviews; Marketing; Medical imaging; Nausea; Obesity; Observational studies; Pain; Pancreatitis; Patients; Ultrasonic imaging; Vomiting; Weight control; United States > US; glucagon-like peptide-1 receptor agonist (glp-1 ra); liraglutide; pancreatitis; complications; diabetes mellitus type 2
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.38263

Liraglutide is an anti-diabetic medication used for the treatment of type 2 diabetes mellitus, obesity, and chronic weight management. It is a glucagon-like peptide-1 (GLP-1) agonist that helps reduce postprandial hyperglycemia for up to 24 h after administration. It stimulates endogenous insulin secretion according to glucose levels, and also delays gastric emptying and suppresses prandial glucagon secretion. Some of the common complications associated with liraglutide include hypoglycemia, headache, diarrhea, nausea, and vomiting. Uncommon adverse effects include pancreatitis, kidney failure, pancreatic cancer, and injection site reactions. In this article, we discussed a case of a 73-year-old male with a history of uncontrolled type 2 diabetes mellitus on long-term insulin and liraglutide who presented with abdominal pain, subjective fevers, dry heaves, tachycardia, and mildly reduced oxygen saturation. The patient was diagnosed with pancreatitis on the basis of laboratory and imaging findings. Liraglutide was discontinued, and the patient received supportive care with significant clinical improvement. The use of GLP-1 inhibitors has been increasing not only for diabetes mellitus management, but also for its promising effect on weight management. The literature review endorses our case report findings, and also discusses other complications of liraglutide. Therefore, we recommend to be cognizant of these side-effects upon starting liraglutide.