Process Intensification and Miniaturization of Chemical and Biochemical Processes

• Published in: Computer Aided Chemical Engineering Vol. 46; pp. 1801 - 1806
• Main Authors: Strniša, Filip, Urbič, Tomaž, Žnidaršič-Plazl, Polona, Plazl, Igor
• Format: Book Chapter
• Language: English
• Published: 2019
• Subjects: miniaturization; model-based design; process intensification; process intensification; miniaturization; model-based design
• ISBN: 9780128186343; 0128186348
• ISSN: 1570-7946
• DOI: 10.1016/B978-0-12-818634-3.50301-5

In this work, the microscale (bio)process development based on scale-up/numbering-up concept in combination with model-based optimization is presented. The main features of microscale systems are reflected in fluid dynamics, therefore the understanding of fundamental mechanisms involved in fluid flow characteristics at the micro scale is essential since their behaviour affects the transport phenomena and microfluidic applications. Theoretical description of transport phenomena and the kinetics at the micro scale is discussed and illustrated on the cases of a lattice Boltzmann simulations for flow distribution in the packed bed microreactor “between two-plates” and the biocatalytic enzyme surface reaction.