Infections on the rise: Raoultella spp., clinical and microbiological findings from a retrospective study, 2010-2014

• Published in: Infectious diseases (London, England) Vol. 48; no. 1; pp. 87 - 91
• Main Authors: Boattini, Matteo, Almeida, André, Cardoso, Catarina, Cruz, Cristiano Silva, Machado, Catarina, Vesza, Zsófia, Tosatto, Valentina, Maia, Dionísio, Cardoso, Sara, Pinto, Margarida, Moura, Rita Barata, Garcia, Teresa, Guerreiro, António Sousa
• Format: Journal Article
• Language: English
• Published: England 2016
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; Bacteremia - etiology; Cystitis - microbiology; Diabetes Complications - microbiology; Drug Resistance, Multiple, Bacterial - drug effects; Enterobacteriaceae - classification; Enterobacteriaceae - drug effects; Enterobacteriaceae - isolation & purification; Enterobacteriaceae Infections - diagnosis; Enterobacteriaceae Infections - epidemiology; Enterobacteriaceae Infections - microbiology; Enterobacteriaceae Infections - mortality; Female; Humans; Male; Middle Aged; Pneumonia, Bacterial - microbiology; Portugal - epidemiology; Retrospective Studies; Tertiary Care Centers; Time Factors; Transplant Recipients; Portugal; multiple drug resistance; infection; Raoultella; gram-negative; Enterobacteriaceae
• ISSN: 2374-4235; 2374-4243
• DOI: 10.3109/23744235.2015.1082619

We performed a retrospective analysis of clinical and laboratory data over 5 years in a tertiary centre to assess clinical and microbiological characteristics of patients with Raoultella spp. infection. Raoultella spp. were deemed responsible for clinical infections in 57 patients (R. planticola, n = 32 and R. ornithinolytica, n = 25). The most prevalent diagnoses for R. planticola were cystitis (50%; n = 16) followed by bacteraemia and pneumonia (9.4%; n = 3); for R. ornithinolytica, cystitis (36%; n = 9) followed by pneumonia (24%; n = 6). Immunodeficiency was present in 18 patients (56.3%) with R. planticola and in 16 patients (64%) with R. ornithinolytica infection. Of these, 55.6% and 37.5% had diabetes and 27.8% and 18.% were solid organ transplant recipients, respectively. All isolates were sensitive to third-generation cephalosporins, fluoroquinolones and aminoglycosides. Mortality of infections with R. planticola (n = 5; 15.6%) was higher than for R. ornithinolytica (n = 2; 8.0%), but the difference was not statistically significant.