Postinfectious diffuse proliferative glomerulonephritis and acute renal failure in an HIV patient

• Published in: Clinical nephrology Vol. 61; no. 4; p. 278
• Main Authors: Enríquez, R, Cabezuelo, J B, Escolano, C, Pérez, M, Amorós, F, Gutiérrez-Rodero, F, Reyes, A
• Format: Journal Article
• Language: English
• Published: Germany 01-04-2004
• Subjects: Acute Kidney Injury - etiology; Adult; Biopsy; Female; Glomerulonephritis - drug therapy; Glomerulonephritis - etiology; Glomerulonephritis - immunology; Glucocorticoids - therapeutic use; HIV Infections - complications; Humans; Kidney - pathology; Methylprednisolone - therapeutic use; Prednisone - therapeutic use; Respiratory Tract Infections - complications
• ISSN: 0301-0430
• DOI: 10.5414/CNP61278

Postinfectious proliferative glomerulonephritis may occur in HIV-infected patients, although it is not a common cause of severe acute renal failure in them. We report a woman with HIV infection, who developed hypocomplementemic acute nephritic syndrome 10 days after an upper respiratory infection. Systemic diseases were excluded. The serum creatinine level increased to 6.6 mg/dl. Renal biopsy showed diffuse endocapillary proliferative glomerulonephritis, with mesangial and capillary walls, granular deposits of IgG and C3 by immunofluorescence. She was given corticosteroids with progressive normalization of her renal function. No opportunistic infections have occurred during 1-year follow-up.