Joint kinematics and SPM analysis of gait in children with and without Down syndrome

• Published in: Human movement science Vol. 95; p. 103213
• Main Authors: Beerse, Matthew, Larsen, Kaylee, Alam, Tasnuva, Talboy, Amy, Wu, Jianhua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-06-2024
• Subjects: Ankle Joint - physiopathology; Ankle load; Biomechanical Phenomena - physiology; Child; Coordination; Cross-Sectional Studies; Down syndrome; Down Syndrome - physiopathology; Female; Gait - physiology; Hip Joint - physiopathology; Humans; Knee Joint - physiopathology; Male; Preadolescence; Range of Motion, Articular - physiology; Walking - physiology; Walking speed; Walking Speed - physiology; Weight-Bearing - physiology; Preadolescence; Down syndrome; Ankle load; Coordination; Walking speed
• ISSN: 0167-9457; 1872-7646; 1872-7646
• DOI: 10.1016/j.humov.2024.103213

Individuals with Down syndrome (DS) walk with altered gait patterns compared to their typically developing (TD) peers. While walking at faster speeds and with external ankle load, preadolescents with DS demonstrate spatiotemporal and kinetic improvements. However, evidence of joint kinematic adjustments is unknown, which is imperative for targeted rehabilitation design.
How does increasing walking speed and adding ankle load affect the joint kinematics of children with and without DS during overground walking?
In this cross-sectional observational study, thirteen children with DS aged 7–11 years and thirteen age- and sex-matched TD children completed overground walking trials. There were two speed conditions: normal speed and fast speed (as fast as possible without running). There were two load conditions: no load and ankle load (2% of body mass added bilaterally above the ankle). A motion capture system was used to register the ankle, knee, and hip joint angles in the sagittal plane. Peak flexion/extension angles, range of motion, and timing of peak angles were identified. In addition, statistical parametric mapping (SPM) was conducted to evaluate the trajectory of the ankle, knee, and hip joint angles across the entire gait cycle.
SPM analysis revealed the DS group walked with greater ankle, knee, and hip flexion compared to the TD group for most of the gait cycle, regardless of condition. Further, increasing walking speed led to improved ankle joint kinematics in both groups by shifting peak plantarflexion closer to toe-off. However, knee extension during stance was challenged in the DS group. Adding ankle load improved hip and knee kinematics in both groups but reduced peak plantarflexion around toe-off. The kinematic adjustments in the DS group suggest specific motor strategies to accommodate their neuromuscular deficits, which can provide a foundation to design targeted gait-based interventions for children with DS.
•Children with Down syndrome walked with a distinct joint pattern compared to peers.•Faster walking speed improved ankle kinematics, but challenged the knee extensors.•Ankle load improved hip and knee kinematics, but challenged ankle plantarflexors.•Intervention design should consider the effects of employing speed and ankle load.