Investigations to the synthesis of n.c.a. [18F]FClO3 as electrophilic fluorinating agent

• Published in: Applied radiation and isotopes Vol. 66; no. 2; pp. 152 - 157
• Main Authors: Hiller, A, Fischer, C, Jordanova, A, Patt, J T, Steinbach, J
• Format: Journal Article
• Language: English
• Published: England 01-02-2008
• Subjects: Electrochemistry; Fluorine Radioisotopes - chemistry; Humans; Perchlorates - chemical synthesis; Perchlorates - chemistry; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry
• ISSN: 0969-8043
• DOI: 10.1016/j.apradiso.2007.08.016

An approach to synthesize the electrophilic fluorinating agent no-carrier-added (n.c.a.) [18F]perchloryl fluoride ([18F]FClO3) in superacidic media in the presence of KClO4 or anhydrous perchloric acid starting from [18F]fluoride was demonstrated in this study. However, the radiochemical yields were low (1-6%) and poorly reproducible. Fluorosulphonic acid proved to be an essential intermediate as revealed by non-radioactive experiments. A key problem in the preparation of [18F]FClO3 is the assumed kinetic inhibition due to the unfavourable stoichiometric ratio of the ClO4 moiety to [18F]HSO3F.