Phenytoin toxicity with mandibular tremor secondary to intravenous administration
The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postopera...
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| Published in: | International journal of clinical pharmacology and therapeutics Vol. 40; no. 1; p. 18 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Germany
01-01-2002
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| Abstract | The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postoperative intravenous administration of the drug with no modification of the oral dose. This report emphasizes the need for careful surveillance of phenytoin-induced toxicity during parenteral therapy, especially in debilitated patients. |
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| AbstractList | The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postoperative intravenous administration of the drug with no modification of the oral dose. This report emphasizes the need for careful surveillance of phenytoin-induced toxicity during parenteral therapy, especially in debilitated patients. |
| Author | Türe, U Pamir, N Onat, F Türkdogan, D |
| Author_xml | – sequence: 1 givenname: D surname: Türkdogan fullname: Türkdogan, D organization: Institute of Neurological Sciences, University of Marmara, Maltepe, Istanbul, Turkey – sequence: 2 givenname: F surname: Onat fullname: Onat, F – sequence: 3 givenname: U surname: Türe fullname: Türe, U – sequence: 4 givenname: N surname: Pamir fullname: Pamir, N |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11837377$$D View this record in MEDLINE/PubMed |
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| Snippet | The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations... |
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| SubjectTerms | Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Anticonvulsants - blood Epilepsy, Complex Partial - drug therapy Humans Injections, Intravenous Male Middle Aged Phenytoin - administration & dosage Phenytoin - adverse effects Phenytoin - blood Tremor - chemically induced |
| Title | Phenytoin toxicity with mandibular tremor secondary to intravenous administration |
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