Phenytoin toxicity with mandibular tremor secondary to intravenous administration

The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postopera...

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Bibliographic Details
Published in:	International journal of clinical pharmacology and therapeutics Vol. 40; no. 1; p. 18
Main Authors:	Türkdogan, D, Onat, F, Türe, U, Pamir, N
Format:	Journal Article
Language:	English
Published:	Germany 01-01-2002
Subjects:	Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Anticonvulsants - blood Epilepsy, Complex Partial - drug therapy Humans Injections, Intravenous Male Middle Aged Phenytoin - administration & dosage Phenytoin - adverse effects Phenytoin - blood Tremor - chemically induced
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Summary:	The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postoperative intravenous administration of the drug with no modification of the oral dose. This report emphasizes the need for careful surveillance of phenytoin-induced toxicity during parenteral therapy, especially in debilitated patients.
ISSN:	0946-1965
DOI:	10.5414/CPP40018