Impact of a 1,3,4-Thiadiazine Compound on Oxidative Stress Intensity in Experimental Type 2 Diabetes Mellitus

• Published in: Pharmaceutical chemistry journal Vol. 57; no. 3; pp. 353 - 357
• Main Authors: Emelianov, V. V., Gette, I. F., Danilova, I. G., Sidorova, L. P., Tseiler, T. A., Mukhlynina, E. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2023; Springer
• Subjects: Analysis; Animal experimentation; Antioxidants; Enzymes; Glycosylated hemoglobin; Hyperglycemia; Medicine; Niacinamide; Organic Chemistry; Pharmacology/Toxicology; Pharmacy; Superoxide; Thiols; Type 2 diabetes; 1,3,4-thiadiazine hydrobromide; type 2 diabetes mellitus; 2-morpholino-5-phenyl-6; antioxidants; oxidative stress
• ISSN: 0091-150X; 1573-9031
• DOI: 10.1007/s11094-023-02889-y

The effect of the synthetic compound 2-morpholino-5-phenyl-6
H
-1,3,4-thiadiazine hydrochloride (L17) on rats with a streptozotocin-nicotinamide model of type 2 diabetes mellitus (DM2) was studied. The experiment was performed on 50 male Wistar rats. L17 was administered intramuscularly to diabetic rats at a dose of 40 mg/kg. Modeling DM2 revealed hyperglycemia, accumulation of glycated hemoglobin (HbA
1c
) and malondialdehyde (MDA); a decreased content of thiols; and compensatory activation of antioxidant defense (AOD) enzymes [superoxide dismutase (SOD), catalase, glutathione peroxidase] in erythrocytes. Administration of L17 to diabetic rats was accompanied by a decrease in hyperglycemia, normalization of HbA
1c
and MDA levels and AOD enzyme activity, and prevention of thiol depletion. Correction of hyperglycemia and imbalance in the free-radical oxidation(AOD system in the experiment made further study of the mechanism of the antidiabetic action of L17 promising.