Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzoxazolon-3-yl) propanamide derivatives

• Published in: Archives of pharmacal research Vol. 27; no. 11; pp. 1086 - 1092
• Main Authors: Önkol, Tijen, Fethi Sahin, M, Yildirim, Engin, Erol, Kevser, Ito, Shigero
• Format: Journal Article
• Language: English
• Published: Korea (South) Pharmaceutical Society of Korea 01-11-2004
• Subjects: Amides - chemical synthesis; Amides - chemistry; Amides - pharmacology; analgesic effect; Analgesics - chemical synthesis; Analgesics - chemistry; Analgesics - pharmacology; Animals; aspirin; Behavior, Animal - drug effects; Benzoxazoles - chemical synthesis; Benzoxazoles - chemistry; Benzoxazoles - pharmacology; chemical structure; Mice; Pain Measurement - methods; spectral analysis; Structure-Activity Relationship; tail
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/BF02975109

In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and¹H-NMR spectral data and microanalysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of antinociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound5e, 5g, and5h have been found to be significantly more active than the others and the standards in all the tests.