Non-exclusion paternity case with a triple genetic incompatibility

• Published in: International Congress series Vol. 1261; pp. 511 - 513
• Main Authors: Jacewicz, R., Berent, J., Prosniak, A., Dobosz, T., Kowalczyk, E., Szram, S.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-04-2004
• Subjects: D18S51; D7S21; D8S1179; Paternity investigation; Poland; Triple mutation; Poland; D18S51; Paternity investigation; D8S1179; D7S21; Triple mutation
• ISSN: 0531-5131; 1873-6157
• DOI: 10.1016/S0531-5131(03)01649-2

This work presents a paternity determination case in which the total analysis of 30 DNA markers detected three genetic inconsistencies between the putative father and the child, two in STR markers, D8S1179 and D18S51, and one in RFLP marker, D7S21. The paternity index, including the mutation rates of the systems mentioned above, amounted to 2.374×10
10, which corresponds with the paternity probability higher than 99.99999999%. The case proves that great care should be taken when the non-fatherhood status is ascertained on the basis of the “three exclusion rule”. It suggests also that the best solution is to calculate the appropriate statistical estimations in every case.