From regulation to ruin: a rogue sigma factor causes cell death in Bacillus subtilis

A rogue, plasmid-encoded sigma factor that kills Bacillus subtilis is the focus of a new study by A. T. Burton, D. Pospíšilová, P. Sudzinová, E. V. Snider, A. M. Burrage, L. Krásný, and D. B. Kearns (J Bacteriol 205:e00112-23, 2023, https://doi.org/10.1128/jb.00112-23). The authors demonstrate that...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of bacteriology Vol. 205; no. 10; pp. 1 - e0020323
Main Authors:	Camp, Amy H., Ellermeier, Craig D.
Format:	Journal Article
Language:	English
Published:	Washington American Society for Microbiology 01-10-2023
Subjects:	Bacillus subtilis Bacteriology Cell death DNA-directed RNA polymerase Sigma factor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A rogue, plasmid-encoded sigma factor that kills Bacillus subtilis is the focus of a new study by A. T. Burton, D. Pospíšilová, P. Sudzinová, E. V. Snider, A. M. Burrage, L. Krásný, and D. B. Kearns (J Bacteriol 205:e00112-23, 2023, https://doi.org/10.1128/jb.00112-23). The authors demonstrate that SigN is toxic in its own right, causing cell death by potently outcompeting the housekeeping sigma factor for access to RNA polymerase.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Commentary-3 content type line 23 The authors declare no conflict of interest.
ISSN:	0021-9193 1098-5530
DOI:	10.1128/jb.00203-23