Lentil lectin inhibits cells producing graft-versus-host reaction but does not suppress hematopoietic stem cells in mice

Lentil lectin inhibits cells producing graft-versus-host reaction but does not suppress hematopoietic stem cells in mice

Treatment of mouse donors or recipients of allogeneic spleen cells with repeated injections of lentil lectin markedly suppressed regional and systemic graft-versus-host reactions. The lectin acted selectively on lymphoid cells; hematopoietic stem cells were largely left unaffected. Repeated administ...

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Bibliographic Details
Published in:Immunobiology (1979) Vol. 173; no. 1; p. 35
Main Authors: Sůla, K, Paluska, E, Nouza, K, Danĕk, P F
Format: Journal Article
Language:English
Published: Netherlands 01-10-1986
Subjects:
Adjuvants, Immunologic
Animals
Erythrocyte Count
Female
Graft vs Host Reaction
Hematopoietic Stem Cells
Immune Tolerance
Injections, Intraperitoneal
Injections, Intravenous
Lectins - administration & dosage
Lectins - immunology
Lectins - pharmacology
Leukocyte Count
Mice
Mice, Inbred Strains
Plant Lectins
Spleen - cytology
Tissue Donors
Transplantation, Homologous
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Description
Summary:Treatment of mouse donors or recipients of allogeneic spleen cells with repeated injections of lentil lectin markedly suppressed regional and systemic graft-versus-host reactions. The lectin acted selectively on lymphoid cells; hematopoietic stem cells were largely left unaffected. Repeated administration of the lectin decreased the number of lymphocytes and red blood cells and the amount of hemoglobin; other white blood cells increased in number.
ISSN:0171-2985
DOI:10.1016/S0171-2985(86)80087-0