MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS

• Published in: Infekt͡s︡ii͡a︡ i immunitet Vol. 4; no. 3; pp. 221 - 228
• Main Authors: Titarenko, O. T., Dyakova, M. E., Manicheva, O. A., Esmedlyaeva, D. S., Dogonadze, M. Z., Alexeyeva, N. P., Perova, T. L., Melnikova, N. N.
• Format: Journal Article
• Language: English; Russian
• Published: Sankt-Peterburg : NIIÈM imeni Pastera 15-08-2014
• Subjects: acute phase proteins; genotype; tuberculosis; virulence
• ISSN: 2220-7619; 2313-7398
• DOI: 10.15789/2220-7619-2014-3-221-228

Host-pathogen relations were analyzed on basis of the results of examinations of 42 patients with newly diagnosed, previously untreated infiltrative pulmonary tuberculosis (IPT) with regard for the biological characteristics of Mycobacterium tuberculosis (MBT) and the biomarkers of the inflammatory reaction — the acute phase proteins (APPs). The genotypes of MBT (Beijing and the others) and the efficacy of threeonth antituberculosis therapy were used as the grouping factors. Genotype Beijing MBT patients were significantly often characterised by multiple drug resistant, had widespread pulmonary damage and association of MBT cytoxicity with the effect of therapy. The patients with the best postreatment effect had initial (pretreatment) APPs levels in the range of the referent ones. These conclusions were confirmed by analysis of the correlation pleads of the characteristics of the “host-pathogen” system and their discriminant analysis with regard for MBT genotypes and results of antituberculosis three-month therapy. It was shown that the constellation of four host’s APP characteristics (haptoglobin, ceruloplasmin, elastase and adenoaminase activities) has above 90% prognostic efficacy of treatment in spite of MBT genotype. It is suggested that in IPT patients the first component of the “host-pathogen” system reflecting the reaction of the patient’s organism to the MBT induced inflammatory process is more prognostically important.