Pupillary Unrest in Ambient Light and Prediction of Opioid Responsiveness: Case Report on Its Utility in the Management of 2 Patients With Challenging Acute Pain Conditions

Pupillary Unrest in Ambient Light and Prediction of Opioid Responsiveness: Case Report on Its Utility in the Management of 2 Patients With Challenging Acute Pain Conditions

Pupillary unrest in ambient light (PUAL), the normal pattern of pupil diameter fluctuation present in awake humans, has been proposed as a marker of central opioid effect. We report 2 cases in which PUAL identified the appropriate pain management for 2 patients, each with unique, challenging acute p...

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Bibliographic Details
Published in:A&A practice Vol. 10; no. 10; pp. 279 - 282
Main Authors: McKay, Rachel Eshima, Neice, Andrew E., Larson, Merlin D.
Format: Journal Article
Language:English
Published: United States International Anesthesia Research Society 15-05-2018
Online Access:Get full text
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Summary:Pupillary unrest in ambient light (PUAL), the normal pattern of pupil diameter fluctuation present in awake humans, has been proposed as a marker of central opioid effect. We report 2 cases in which PUAL identified the appropriate pain management for 2 patients, each with unique, challenging acute pain conditions. In both cases, PUAL accurately predicted opioid responsiveness, suggesting an effective, individualized analgesic approach for both patients.
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ISSN:2575-3126
2575-3126
DOI:10.1213/XAA.0000000000000710