Value of SSTR2A and Claudin - 1 in Differentiating Meningioma from Schwannoma and Hemangiopericytoma

• Published in: Open access Macedonian journal of medical sciences Vol. 6; no. 2; pp. 248 - 253
• Main Authors: Anis, Shady E, Lotfalla, Mira, Zain, Muhammad, Kamel, Nora N, Soliman, Ahmed A
• Format: Journal Article
• Language: English
• Published: Macedonia Republic of Macedonia 15-02-2018
• Subjects: Basic Science; Hemangiopericytoma; Claudin - 1; SSTR2A; Meningioma; Schwannoma
• ISSN: 1857-9655; 1857-9655
• DOI: 10.3889/OAMJMS.2018.062

The distinction between meningioma, schwannoma and solitary fibrous tumour/ hemangiopericytoma can be challenging in some cases. This study evaluates the expression of Somatostatin receptor 2A (SSTR2A) and Claudin-1 in these different tumours.
Thirty-five cases of meningioma, 10 cases of intracranial schwannoma and 10 cases of hemangiopericytoma were assessed. The immunohistochemical expression of SSTR2A and Claudin-1 was evaluated and scored according to the percentage of immunostained tumour cells (0: 1+, 2+ and 3). The intensity of staining was classified as weak, moderate and strong.
Positivity for SSTR2A and Claudin-1 was encountered in 89% and 49% of meningiomas respectively. None of the schwannomas or hemangiopericytomas was positive for any of both markers. All grade I and II meningiomas were positive for SSTR2A, and only 20% of grade III showed positive staining (p < 0.05). Claudin-1 positivity was detected in 50%, 43% and 60% of grade I, II and III meningioma respectively, with significantly higher intensity in grade III (p < 0.05).
SSTR2A is highly sensitive and specific for meningioma. Claudin-1 is highly specific for meningioma, with low sensitivity. The adjunctive use of both markers can be very helpful in the diagnosis of meningioma and its distinction from schwannoma and hemangiopericytoma.