Early acute kidney injury after liver transplantation in patients with normal preoperative renal function

• Published in: Clinics and research in hepatology and gastroenterology Vol. 43; no. 4; pp. 475 - 482
• Main Authors: Tan, Lingcan, Yang, Yaoxin, Ma, Gang, Zhu, Tao, Yang, Jiayin, Liu, Haibei, Zhang, Weiyi
• Format: Journal Article
• Language: English
• Published: France 01-08-2019
• Subjects: KDIGO; Acute kidney injury; Clinical outcomes; Risk factors; Liver transplantation
• ISSN: 2210-7401; 2210-741X
• DOI: 10.1016/j.clinre.2018.07.009

Acute kidney injury (AKI) commonly occurs in patients after liver transplantation (LT). However, few studies have focused on AKI and its correlation with clinical outcomes under the Kidney Disease Improving Global Outcomes (KDIGO) criteria. This study aimed to identity the incidence, risk factors, and impacts of early AKI on outcomes in LT recipients with normal preoperative renal function, according to the KDIGO criteria.
Clinical and laboratory data of 227 patients with normal preoperative renal function who underwent LT from January 2011 to January 2015 were retrospectively analyzed.
During the first week after LT, 106 patients (46.7%) developed AKI based on the KDIGO criteria. A multivariate analysis revealed that BMI of > 25, prolonged inferior vena cava clamping, prolonged cold ischemia time, and post-operative RBC requirements > 10 units were independent risk factors for AKI after LT. The area under the receiver operating characteristic curve for the predictive ability of AKI under these risk factors was 0.748. The occurrence of AKI was associated with longer mechanical ventilation time and post-operative ICU stay, increased post-operative 30-day mortality and decreased long-term patient survival.
Even in patients with normal preoperative renal function, AKI was a frequent complication in LT recipients and had both negative short- or long-term effects on patient outcomes, also the severity of AKI had a dose-response relationship with worse outcomes. Patients with BMI > 25, prolonged inferior vena cava clamping, prolonged cold ischemia time, or post-operative RBC requirement > 10 units should be pay particular attention, which may assist in achieving better clinical outcomes.