A New Synthesis of 3,5-Diaryl-pyrrole-2-carboxylic Acids and Esters

A New Synthesis of 3,5-Diaryl-pyrrole-2-carboxylic Acids and Esters

A new two-step synthesis of pyrrole-2-carboxylic acids, steps via 1,3 dipolar cycloaddition of azomethine ylides to nitro-styrenes and oxidation of the resulting pyrrolidines with alkaline hydrogen peroxide is described. The oxidation of cycloadducts 3 by the means of MnO 2 under different condition...

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Bibliographic Details
Published in:Tetrahedron Vol. 56; no. 43; pp. 8545 - 8553
Main Authors: Fejes, Imre, Tőke, László, Blaskó, Gábor, Nyerges, Miklós, Siek Pak, Chwang
Format: Journal Article
Language:English
Published: Elsevier Ltd 20-10-2000
Subjects:
cycloadditions
oxidation
pyrroles
pyrrolidines
oxidation
cycloadditions
pyrroles
pyrrolidines
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Summary:A new two-step synthesis of pyrrole-2-carboxylic acids, steps via 1,3 dipolar cycloaddition of azomethine ylides to nitro-styrenes and oxidation of the resulting pyrrolidines with alkaline hydrogen peroxide is described. The oxidation of cycloadducts 3 by the means of MnO 2 under different conditions also has been examined.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)00781-X