Synthesis and reactions of platinum(IV) complexes with sodium ascorbate

• Published in: Inorganica Chimica Acta Vol. 340; pp. 65 - 69
• Main Authors: Arendse, Malcolm J, Anderson, Gordon K, Majola, Raquel N, Rath, Nigam P
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25-11-2002
• Subjects: Antitumor activity; Ascorbic acid; Oxalate; Oxidation; Platinum complexes; Antitumor activity; Oxidation; Ascorbic acid; Oxalate; Platinum complexes
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/S0020-1693(02)01058-7

The platinum(IV) complexes [PtCl
2(OH)
2(
N
∩
N)] (
N
∩
N=en,
N,
N-dmen,
N,
N′-dmen) were prepared by oxidation of [PtCl
2(
N
∩
N)] with hydrogen peroxide. The complexes were characterized by multinuclear NMR and infrared spectroscopy, as well as microanalysis. The reactions of these compounds with sodium ascorbate were monitored spectroscopically. Reduction of the platinum(IV) complexes by sodium ascorbate occurred only slowly. An oxalatoplatinum(IV) complex [Pt(C
2O
4)Cl(OH)(
N,
N-dmen)]·H
2O was isolated from the reaction of [PtCl
2(OH)
2(
N,
N-dmen)] and sodium ascorbate and characterized by an X-ray diffraction study.
The platinum(IV) complexes [PtCl
2(OH)
2(
N
∩
N)] (
N
∩
N=en,
N,
N-dmen,
N,
N′-dmen) have been prepared by oxidation of the corresponding platinum(II) precursors with hydrogen peroxide, and their reactions with sodium ascorbate were monitored spectroscopically. Reduction of the platinum(IV) complexes occurred only slowly, and the oxalatoplatinum(IV) derivative [Pt(C
2O
4)Cl(OH)(
N,
N-dmen)]
H
2O was isolated and characterized by an X-ray diffraction study.