Myelin lipids in the brain after transplacental intoxication with ethylnitrosourea

Myelin lipids in the brain after transplacental intoxication with ethylnitrosourea

At day 15 of gestation pregnant mice were injected with a single intravenous dose of ethylnitrosourea (ENU) (80 mg/kg of body weight). The lipid composition of the myelin fraction isolated by means of differential centrifugation from brains of their offsprings was studied. The transplacentally intox...

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Bibliographic Details
Published in:Experimentelle Pathologie Vol. 15; no. 2; p. 105
Main Authors: Wender, M, Adamczewska-Goncerzewicz, Z, Mularek, O, Sedzik, J, Pancrac, J
Format: Journal Article
Language:English
Published: Germany 1978
Subjects:
Animals
Brain Chemistry
Cerebrosides - analysis
Ethylnitrosourea - poisoning
Female
Lipids - analysis
Male
Maternal-Fetal Exchange
Mice
Myelin Sheath - analysis
Myelin Sheath - drug effects
Nitrosourea Compounds - poisoning
Plasmalogens - analysis
Pregnancy
Sulfoglycosphingolipids - analysis
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Summary:At day 15 of gestation pregnant mice were injected with a single intravenous dose of ethylnitrosourea (ENU) (80 mg/kg of body weight). The lipid composition of the myelin fraction isolated by means of differential centrifugation from brains of their offsprings was studied. The transplacentally intoxicated mice developed severe changes in the lipid composition of their central myelin sheaths, such as a markedly decreased galactolipid (both cerebroside and sulfatide) as well as plasmalogen contents. The results show, that besides being a well known carcinogenic agent, ENU is capable of affecting the lipid metabolism of the developing central nervous system. The resultant effect is the formation of a chemically defective myelin sheath.
ISSN:0014-4908
DOI:10.1016/S0014-4908(78)80074-X