A randomized controlled clinical trial to evaluate blood pressure changes in patients undergoing extraction under local anesthesia with vasopressor use

• Published in: The Journal of craniofacial surgery Vol. 25; no. 3; pp. 1108 - 1110
• Main Authors: Uzeda, Marcelo José, Moura, Brenda, Louro, Rafael Seabra, da Silva, Licínio Esmeraldo, Calasans-Maia, Mônica Diuana
• Format: Journal Article
• Language: English
• Published: United States 01-05-2014
• Subjects: Adult; Anesthesia, Local - methods; Anesthetics, Local - pharmacology; Blood Pressure - drug effects; Brazil; Dentistry; Epinephrine - pharmacology; Female; Heart Rate - drug effects; Hemodynamics - drug effects; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Lidocaine - pharmacology; Male; Middle Aged; Oral Surgical Procedures - methods; Vasoconstrictor Agents - administration & dosage; Young Adult; Brazil
• ISSN: 1049-2275; 1536-3732
• DOI: 10.1097/SCS.0000000000000736

The control of hypertensive patients' blood pressure and heart rate using vasoconstrictors during surgical procedures under anesthesia is still a major concern in everyday surgical practice. This clinical trial aimed to evaluate the variation of blood pressure and heart rate in nonhypertensive and controlled hypertensive voluntary subjects undergoing oral surgery under local anesthesia with lidocaine hydrochloride and epinephrine at 1:100,000 (Alphacaine; DFL, Brazil), performed in the Oral Surgery Department, Dentistry School, Fluminense Federal University. In total, 25 voluntary subjects were divided into 2 groups: nonhypertensive (n = 15) and controlled hypertensives (n = 10). Blood pressure and heart rate were measured at 4 different times: T0, in the waiting room; T1, after placement of the surgical drapes; T2, 10 minutes after anesthesia injection; and T3, at the end of the surgical procedure. A statistically significant difference (P < 0.05) between the groups was found at times T0 and T2 for the systolic pressure but only at time T0 for the diastolic pressure. The assessment of the heart rate of both groups showed a statistically significant difference (P < 0.05) at time T1. An analysis of the employed anesthetic volume indicated no statistically significant difference (P > 0.05) between the amount administered to nonhypertensive and hypertensive subjects. It was concluded that the local anesthetics studied could safely be used in controlled hypertensive and nonhypertensive patients in compliance with the maximum recommended doses.